7169-97-3 Usage
Uses
Used in Pharmaceutical Industry:
2-ACETYLAMINO-5-BROMOPYRIDINE is used as a chemical reagent for the synthesis of novel Bcr-Abl inhibitors with diacylated piperazine flexible linkers. These inhibitors are designed to target and inhibit the activity of the Bcr-Abl enzyme, which is implicated in the development of certain cancers, such as chronic myeloid leukemia (CML).
Additionally, 2-ACETYLAMINO-5-BROMOPYRIDINE is utilized in the production of hetero-monocyclic derivatives, which have demonstrated even greater potency as inhibitors of the BCR-ABL enzyme. This makes them promising candidates for the development of more effective cancer treatments, particularly for patients with drug-resistant forms of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 7169-97-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,6 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7169-97:
(6*7)+(5*1)+(4*6)+(3*9)+(2*9)+(1*7)=123
123 % 10 = 3
So 7169-97-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H7BrN2O/c1-5(11)10-7-3-2-6(8)4-9-7/h2-4H,1H3,(H,9,10,11)
7169-97-3Relevant academic research and scientific papers
A new, one-step, effective protocol for the iodination of aromatic and heterocyclic compounds via aprotic diazotization of amines
Krasnokutskaya, Elena A.,Semenischeva, Nadya I.,Filimonov, Victor D.,Knochel, Paul
, p. 81 - 84 (2008/01/03)
We have developed a convenient one-step preparation of aromatic and some heterocyclic iodides by the sequential diazotization-iodination of the aromatic amines with a KI/NaNO2/p-TsOH system in acetonitrile at room temperature. This method has general character and allows aryl iodides with either donor or acceptor substituents in various positions to be obtained from the corresponding amines in 50-90% yield. Georg Thieme Verlag Stuttgart.
