208104-11-4Relevant academic research and scientific papers
Potent inhibitors of the MAP kinase p38
Henry, James R.,Rupert, Kenneth C.,Dodd, John H.,Turchi, Ignatius J.,Wadsworth, Scott A.,Cavender, Druie E.,Schafer, Peter H.,Siekierka, John J.
, p. 3335 - 3340 (1998)
The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS
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, (2008/06/13)
The present invention comprises a new class of novel aryl and heteroaryl substituted fused pyrrole compounds useful for the prophylaxis and treatment of diseases or conditions, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the prophylaxis and treatment of diseases or conditions involving inflammation. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of inflammation and other maladies, such as pain and diabetes, using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Synthesis of RWJ 68354: A potent inhibitor of the MAP kinase p38
Henry, James R.,Dodd, John H.
, p. 8763 - 8764 (2007/10/03)
The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mohlau indole synthesis is reported.
