Bioorganic and Medicinal Chemistry Letters p. 3335 - 3340 (1998)
Update date:2022-08-25
Topics:
Henry, James R.
Rupert, Kenneth C.
Dodd, John H.
Turchi, Ignatius J.
Wadsworth, Scott A.
Cavender, Druie E.
Schafer, Peter H.
Siekierka, John J.
The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
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(1979)
