208121-80-6

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 62-57-7 2-Aminoisobutyric acid 

Downstream Products

• 824-75-9 p-fluorobenzamide 
• 1205603-43-5 2-(4-fluorophenyl)-4,4-dimethyl-2-oxazolin-5-one 
• 1240253-00-2 4-fluoro-N-[2-((7-fluoro-1-methyl-2-oxo-5-(4-(trifluoromethoxy)benzyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)amino)-1,1-dimethyl-2-oxoethyl]benzamide 
• 1237005-02-5 4-fluoro-N-(2-{[(3R)-8-fluoro-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]amino}-1,1-dimethyl-2-oxoethyl)benzamide 

Relevant academic research and scientific papers

Cu(II)-promoted oxidative C-N bond cleavage of N-benzoylamino acids to primary aryl amides

A novel protocol for CuCl2-promoted oxidative C-N bond cleavage of N-benzoyl amino acids was developed. It is the first example of using accessible amino acid as an ammonia synthetic equivalent for the synthesis of primary aryl amides via CuCl2-promoted oxidative C-N bond cleavage reaction. The present protocol shows excellent functional group tolerance and provides an alternative method for the synthetic of primary aryl amides in 84-96% yields.

Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature

An efficient palladium-catalyzed ortho-alkoxylation of N-benzoyl α-amino acid derivatives at room temperature has been explored. This novel transformation, using amino acids as directing groups, Pd(OAc)2 as catalyst, alcohols as the alkoxylation reagents, and PhI(OAc)2 as the oxidant, showed wide generality, good functional tolerance, and high monoselectivity and regioselectivity.

Cu(II)-promoted oxidative C-N bond cleavage of N-benzoylamino acids to primary aryl amides

A novel protocol for CuCl2-promoted oxidative C-N bond cleavage of N-benzoyl amino acids was developed. It is the first example of using accessible amino acid as an ammonia synthetic equivalent for the synthesis of primary aryl amides via CuCl2-promoted oxidative C-N bond cleavage reaction. The present protocol shows excellent functional group tolerance and provides an alternative method for the synthetic of primary aryl amides in 84-96percent yields.

BENZODIAZEPIN-2-ON DERIVATIVES

The present invention relates to a compound represented by the formula(I):wherein R1 represents a hydrogen atom or the like;R2 represents lower alkyl or the like;R3 and R4 represent lower alkyl or the like;R5 represents phenyl or the like;R6 represents a hydrogen atom or the like;m is an integer of from 0 to 2;p is an integer of from 1 to 4; and q is an integer of from 1 to 5, or a pharmaceutical acceptable saltthereof, and a DGAT 1 inhibitor comprising the compound.