20815-29-6

Basic information

• Product Name: 3-METHYL-4-ETHYL PYRIDINE
• Synonyms: 4-ethyl-3-methyl-pyridin;Pyridine, 4-ethyl-3-methyl-;3-METHYL-4-ETHYL PYRIDINE;Einecs 244-057-1
• CAS NO: 20815-29-6
• Molecular Formula: C₈H₁₁N
• Molecular Weight: 121.18
• EINECS: 244-057-1
• Mol File: 20815-29-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 194.7 °C at 760 mmHg
• Flash Point: 69.5 °C
• Appearance: /
• Density: 0.919 g/cm³
• Vapor Pressure: 0.608mmHg at 25°C
• Refractive Index: 1.499
• PKA: 6.33±0.18(Predicted)
• CAS DataBase Reference: 3-METHYL-4-ETHYL PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-4-ETHYL PYRIDINE(20815-29-6)
• EPA Substance Registry System: 3-METHYL-4-ETHYL PYRIDINE(20815-29-6)

Safety Data

• Hazardous Substances Data: 20815-29-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H11N/c1-3-8-4-5-9-6-7(8)2/h4-6H,3H2,1-2H3

Upstream product

• 108-99-6 3-Methylpyridine 
• 108-24-7 acetic anhydride 
• 64-17-5 ethanol 
• 2386-64-3 ethylmagnesium chloride 
• 56176-59-1 3-pyrrolidinopent-2-ene 
• 290-38-0 1,2,4-triazine 
• 96-22-0 pentan-3-one 

Downstream Products

• 129255-18-1 1-phenyl-4-(3-methyl-pyridin-4-yl)-pentane 
• 129255-25-0 1-(3-trifluoromethylphenyl)-4-(3-methyl-pyridin-4-yl)-pentane 
• 129254-97-3 3-methyl-4-(4-phenylbutan-2-yl)pyridine 
• 129255-27-2 1-(3,4-dichlorophenyl)-4-(3-methyl-pyridin-4-yl)-pentane 

Relevant articles and documents

Inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction

The invention concerns inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction, characterized by formula I wherein, X, Y and Z independently represent C or N; ------ is an optional double bond; n is 0 or 1; R1, R2, and R4 independently represent hydrogen, a chemical bond, C1-10 alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10 alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, arylalkyl, heterocyclyl, or heteroaryl being optionally substituted; R3, R5, and R6 independently represent hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, heterocyclyl, or heteroaryl being optionally substituted; or R5 and R6 together form a 5- or 6-member aryl, heterocyclyl or heteroaryl group; R is hydrogen or C1-6 alkyl; R* is hydrogen, or C1-6 alkyl, or OH, wherein the optional substituents are preferably selected from the group of one to three OH, C1-6 alkyl, halo, NO2, C1-6 alkoxy, and CF3, or a pharmaceutically acceptable salt thereof.

Regioselective Addition of Grignard Reagents to 1-Acylpyridinium Salts. A Convenient Method for the Synthesis of 4-Alkyl(aryl)pyridines

The addition of Grignard reagents to 1-acylpyridinium salts afforded 1-acyl-2-alkyl(aryl)-1,2-dihydropyridines and 1-acyl-4-alkyl(aryl)-1,4-dihydropyridines.The regioselectivity of this reaction, 1,2- vs. 1,4-addition, was examined and found to be dependent upon the structures of the Grignard reagent and the 1-acyl group.Pyridine, 2-picoline, and 3-picoline were studied, and in most cases, significant amounts of 1,4-addition occurred.When a catalytic amount of cuprous iodide was present, nearly exclusive 1,4-addition resulted.The crude 1,4-dihydropyridines were aromatized by heating with sulfur to provide 4-substituted pyridines and picolines in good yield and high isomeric purity.

Synthetic Applications of N-N Linked Heterocycles. Part 13. N-(2,5-Dimethylpyrrol-1-yl)pyridinium Salts in the Synthesis of 4-Alkyl and 4-Aryl-pyridines via Regiospecific Attack of Grignard Reagents and Organolithium Compounds.

The reaction between N-(2,5-dimethylpyrrol-1-yl)pyridinium salts and alkyl- or aryl-Grignard reagents, or organolithium compounds, gives regiospecifically 1,4-dihydro-intermediates.These may be isolated and decomposed under free-radical conditions to give moderate to good yields of 4-alkyl- and 4-aryl-pyridines.Results are compared with those obtained from a related reaction sequence involving N-(2,6-dimethyl-4-oxopyridin-1-yl)pyridinium salts.