208165-96-2

Basic information

• Product Name: 2-Chloro-4-fluoro-5-methyl-benzoic acid
• Synonyms: 2-Chloro-4-fluoro-5-methyl-benzoic acid
• CAS NO: 208165-96-2
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.5834432
• Mol File: 208165-96-2.mol

Chemical Properties

• Boiling Point: 287.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.403±0.06 g/cm3(Predicted)
• PKA: 2.94±0.25(Predicted)
• CAS DataBase Reference: 2-Chloro-4-fluoro-5-methyl-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-fluoro-5-methyl-benzoic acid(208165-96-2)
• EPA Substance Registry System: 2-Chloro-4-fluoro-5-methyl-benzoic acid(208165-96-2)

Safety Data

• Hazardous Substances Data: 208165-96-2(Hazardous Substances Data)

Upstream product

• 109-72-8 n-butyllithium 
• 201849-18-5 1-bromo-2-chloro-4-fluoro-5-methylbenzene 

Relevant articles and documents

Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient

PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.