208186-86-1Relevant articles and documents
Cholinesterase reactivators derived from pyridine-2-carbaldoxime
Bielavsky, Jiri,Kassa, Jiri,Elsnerova, Iva,Dejmek, Lubos
, p. 199 - 204 (1998)
Monoquaternary reactivators of cholinesterase 3a-3c were prepared by quaternization of substituted pyridine-2-carbaldoximes with an ester (1a, 1b) or carbamoyl (2) function in position 4. A new bisquaternary reactivator, 4-carbamoyl-2′-[(hydroxyimino)methyl]-1,1′-(but-2-ene-1,4-diyl) bispyridinium salt (5), was derived from the unsubstituted pyridine-2-carbaldoxime. The compounds were characterized by UV spectra and ionization constants. The substances exhibit antidote effects in intoxications with organophosphate cholinesterase inhibitors.