208196-20-7

Basic information

• Product Name: (R)-1-chloro-1-(3-trifluoromethylphenyl)ethane
• Synonyms: (R)-1-chloro-1-(3-trifluoromethylphenyl)ethane
• CAS NO: 208196-20-7
• Molecular Weight: 208.611
• Mol File: 208196-20-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-1-chloro-1-(3-trifluoromethylphenyl)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-chloro-1-(3-trifluoromethylphenyl)ethane(208196-20-7)
• EPA Substance Registry System: (R)-1-chloro-1-(3-trifluoromethylphenyl)ethane(208196-20-7)

Safety Data

• Hazardous Substances Data: 208196-20-7(Hazardous Substances Data)

Upstream product

• 1634-04-4 tert-butyl methyl ether 
• 454-91-1 (S)-1-(3-trifluoromethylphenyl)ethanol 
• 108-89-4 picoline 
• 124-63-0 methanesulfonyl chloride 

Relevant articles and documents

Practical Asymmetric Synthesis of (S)-MA20565, a Wide-Spectrum Agricultural Fungicide

A practical asymmetric synthesis of a wide-spectrum agricultural fungicide, (S)-MA20565 (1), is described. The convergent synthesis was achieved starting from commercially available 3-(trifluoromethyl)aniline (7) in 44% overall yield through five steps and 2-bromobenzaldehyde (9) in 48% overall yield through four steps, respectively. (S)-O-[1-(3-Trifluoromethylphenyl)ethyl]hydroxylamine (2), a key intermediate of 1, was prepared via ruthenium(II)-catalyzed asymmetric transfer hydrogenation of 1-(3-trifluoromethylphenyl)ethanone (6) followed by chlorination using methanesulfonyl chloride and oxyamination using potassium acetohydroxamate with high level of stereocontrol.