2082-14-6Relevant academic research and scientific papers
Silver-Induced [3+2] Cycloaddition of Isocyanides with Acyl Chlorides: Regioselective Synthesis of 2,5-Disubstituted Oxazoles
Liu, Jian-Quan,Shen, Xuanyu,Shatskiy, Andrey,Zhou, Enlong,K?rk?s, Markus D.,Wang, Xiang-Shan
, p. 4272 - 4275 (2019/07/19)
A silver-induced cycloaddition of isocyanides with acyl chlorides has been developed. This transition metal-catalyzed strategy provides an effective and scalable approach for the formation of 2,5-disubstituted oxazoles in good to high yields. The employed silver-based MOF catalyst can be efficiently recycled without compromising the yield.
I2-Promoted formal [3+2] cycloaddition of α-methylenyl isocyanides with methyl ketones: a route to 2,5-disubstituted oxazoles
Wu, Xia,Geng, Xiao,Zhao, Peng,Zhang, Jingjing,Wu, Yan-dong,Wu, An-xin
supporting information, p. 3438 - 3441 (2017/03/29)
An I2-promoted formal [3+2] cycloaddition for access to oxazoles has been demonstrated. This is the first example of a Lewis acid-promoted formal [3+2] cycloaddition of isocyanides with methyl ketones involving the C≡N cleavage of isocyanides. The salient feature of this approach is unconventional 2,5-disubstituted oxazole formation from isocyanides and ketones rather than 4,5-substituted oxazoline.
