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Usage

Uses

Used in Industrial Processes:
(1,4-diaminobutyl)phosphonic acid is used as a chelating agent for [binding and sequestering metal ions], which helps in preventing scale formation and corrosion in various industrial applications.
Used in Water Treatment:
(1,4-diaminobutyl)phosphonic acid is used as a corrosion inhibitor for [protecting pipes and equipment from corrosion], thereby extending their lifespan and improving the efficiency of water treatment systems.
Used in Metal Cleaning:
(1,4-diaminobutyl)phosphonic acid is used as a cleaning agent for [removing metal oxides and other impurities], which is essential for maintaining the quality and performance of metal surfaces.
Used in Pharmaceutical and Agrochemical Synthesis:
(1,4-diaminobutyl)phosphonic acid is used as a building block or intermediate for [synthesis of various pharmaceuticals and agrochemicals], contributing to the development of new drugs and pesticides.
Used in Medical Research:
(1,4-diaminobutyl)phosphonic acid is studied as a potential therapeutic agent for [treating conditions such as osteoporosis and cardiovascular diseases], due to its ability to interact with biological systems and influence specific pathways.
It is important to handle (1,4-diaminobutyl)phosphonic acid with care and follow safety guidelines to minimize its potential toxicity and environmental impact.

Upstream product

• 149194-46-7 benzyl (4-amino-1-(diphenoxyphosphoryl)butyl)carbamate 
• 178384-69-5 (1,4-Diamino-butyl)-phosphinic acid 
• 3598-60-5 4-phthalimidobutanal 

Relevant academic research and scientific papers

In the search for new anticancer drugs. 13. Phosphonic and phosphinic analogues of ornithine

Phosphonic (4a,b) and phosphinic (5a-d) analogues of ornithine were synthesized and evaluated for their inhibitory activity against ornithine decarboxylase and against the lymphocytic leukemia P388. The title compounds possess a low degree of inhibition against rat liver ornithine decarboxylase as compared to α-(difluoromethyl)ornithine. Thus, compounds 4a and 5a inhibit by 40% the ornithine decarboxylase activity at a 5 mM concentration. The other derivatives are less potent. Compounds 4a, 4b, 5b, and 5d are inactive against P388 tumor in CD2F1 mice at doses of 50 and 150 mg/kg.

Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from plasmodium falciparum

The malaria parasite Plasmodium falciparum employs two metallo- aminopeptidases, PfA-M1 and PfA-M17, which are essential for parasite survival. Compounds that inhibit the activity of either enzyme represent leads for the development of new antimalarial drugs. Here we report the synthesis and structure-activity relationships of a small library of phosphonic acid arginine mimetics that probe the S1 pocket of both enzymes and map the necessary interactions that would be important for a dual inhibitor.

Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

Two series of α-amino phosphonic and α-amino phosphinic analogs of arginine were prepared and tested as inhibitors of nitric oxide synthase (NOS). Two of the analogs were found to possess inhibitory activity for the neuronal isoform of NOS.

1-Aminoalkylphosphonous Acids. Part 1. Isosteres of the Protein Amino Acids

The synthesis of 1-aminoalkylphosphonous acids, isosteres of the protein amino acids, by addition of hypophosphorous acid to diphenylmethylimines is described.These analogues of glycine, alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, tryptophan, serine, threonine, methionine, cysteine, cystine, glutamic acid, lysine, ornithine, arginine, and proline have been prepared and the analogues of alanine, valine, leucine, phenylalanine, and methionine resolved.The alanine, valine and methionine analogues have interesting antimicrobial activity and the alanine analogue has plant growth inhibiting properties.Oxidation of the appropriate 1-aminoalkylphosphonous acids gave the 1-aminoalkylphosphonic acid analogues of (+/-)-alanine, (-)-alanine, (+/-)-valine, (-)-valine, (+/-)-serine, (+/-)-threonine, (+/-)-lysine, (-)-leucine, and (+/-)-ornithine.

Multi-organ technetium complexes production and use thereof

Chemical complexes, useful as radiopharmaceuticals, are formed by reacting technetium-99m with substituted or unsubstituted alkyl monophosphonic acids and certain ester derivatives thereof. The complexes are formed by reducing pertechnetate ion chemically or electrolytically in the presence of the phosphonic acid. By chemical modification of the phosphonic acid complexing agent, it is possible to "tailor" complexes for kidney, liver or bone imaging. The complexes are normally used in a physiologically acceptable aqueous medium.