20821-96-9

Upstream product

• 21551-47-3 4,4'-Dimethylchalcon 
• 51009-44-0 trans-di(4-methylphenyl)cyclopropane 
• 51009-44-0 C₁₇H₁₈ 
• 104-87-0 4-methyl-benzaldehyde 
• 122-00-9 para-methylacetophenone 
• 622-97-9 1-ethenyl-4-methylbenzene 

Downstream Products

• 16112-20-2 3,5-di(4′-methylphenyl)isoxazole 

Relevant academic research and scientific papers

Heteroannulation of Alkenes with Enynyl Benziodoxolones and Silver Nitrite Involving CC bond Oxidative Cleavage: Entry to 3-Aryl-?2-isoxazolines

A copper-catalyzed [2 + 2 + 1] heteroannulation of alkenes with enynyl benziodoxolones and AgNO2 involving oxidative cleavage of the CC bond promoted by cooperative Zn(OTf)2, KOAc, and 4 ? MS for producing 3-aryl δ2-isoxazolines is reported. Mechanistic s

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range. The b

Transformations of arylcyclopropanes under the action of dinitrogen tetroxide

p-Bromophenylcyclopropane, 1- and 2-methylphenylcyclopropanes, and 1,2-di-p-tolyl- and l,2-bis(p-methoxyphenyl)cyclopropanes react with N2O4with opening of the three-membered ring. Reactions of p-methoxyphenylcyclopropane, 6-cyclopropyl-l,4-benzodioxane, and 2-cyclopropylfluorene yield the corresponding nitroaromatic derivatives with conservation of the cyclopropane ring. The nitration of p-methoxyphenylcyclopropane is accompanied by demethylation. 2-Nitro- and 4-nitrophenylcyclopropanes, as well as l-chloro-2-phenylcyclopropane, do not react with N2O4 under the same conditions. The differences in the behavior of arylcyclopropanes in reactions with N2O4 are explained by the different action of nitrosonium ion in the first reaction step: It acts as either electrophilic species capable of initiating opening of the cyclopropane ring or one-electron oxidant converting the initial arylcyclopropanes into the corresponding radical cations which are precursors of Wheland σ complexes responsible for aromatic nitration. copy;1998 MAHK "Hayka/Interperiodica".

Insertion of Nitrogen Oxide and Nitrosonium Ion into the Cyclopropane Ring: A New Route to 2-Isoxazolines and its Mechanistic Studies

The 9,10-dicyanoanthracene (DCA)-sensitized photoreaction of 1,2-diarylcyclopropanes 1a-d in nitrogen oxide (NO)-saturated CH3CN afforded 3,5-diaryl-2-isoxazolines 2a-d in excellent yields.The reaction of 1a-d with NOBF4 or with a mixture of NO and O2 in

A Novel NO Insertion into Cyclopropane Ring by Use of NOBF4. Formation of 2-Isoxazolines

The reaction of 1,2-diarylcyclopropanes with NOBF4 in CH3CN gave 3,5-diaryl-2-isoxazolines in good yields.For unsymmetrically substituted cyclopropanes, the mixtures of two isomeric isoxazolines were obtained.The mechanism and regioselectivety in this NO

9,10-Dicyanoanthracene-Sensitized NO Insertion into Cyclopropane Ring via Photoinduced Electron Transfer

9,10-Dicyanoanthracene-sensitized photoreaction of electron-rich 1,2-diarylcyclopropanes with NO in acetonitrile afforded 3,5-diaryl-2-isoxazolines in good yields.The cyclopropanes bearing different aryl-substituents gave a mixture of two isomeric 2-isoxa

Synthesis of New Isoxazoles from Isoxazolines, Chalkones, Chalkone Dibromides, Epoxides and Acetylated Ketoximes and Their Conversion into Novel Heterocycles

A convenient and easy conversion of 2-isoxazolines (II) to isoxazoles (V) via N-bromosuccinimide bromination and subsequent dehydrobromination with bases is described.The isoxazoles have also been synthesized from chalkones (I), chalkone dibromides (III)