16112-20-2

Upstream product

• 29559-27-1 1-methyl-4-(nitromethyl)benzene 
• 3594-36-3 1,3-bis(p-methylphenyl)-1,3-propanedione 
• 20821-96-9 3,5-bis(4-methylphenyl)-2-isoxazoline 
• 10403-54-0 phenyl (3-phenyl-2H-aziren-2-yl)methanone 
• 29559-24-8 4-chlorophenylnitromethane 
• 32046-98-3 p-tolyl(3-p-tolyloxiran-2-yl)methanone 
• 21551-47-3 4,4'-Dimethylchalcon 
• 104-87-0 4-methyl-benzaldehyde 
• 97691-66-2 1,3-bis(4-methylphenyl)prop-2-yn-1-one 
• 766-97-2 4-n-methylphenylacetylene 
• 874-60-2 4-methyl-benzoyl chloride 
• 32045-75-3 4,4'-Dimethylchalane dibromide 

Downstream Products

• 16178-29-3 3,5-bis-(4-trans-styryl-phenyl)-isoxazole 
• 85231-83-0 p-Tolyl-(4-p-tolyl-[1,2,5]thiadiazol-3-yl)-methanone 

Relevant academic research and scientific papers

One-pot three-component synthesis of 3,5-disubstituted isoxazoles by a coupling-cyclocondensation sequence

A convenient one-pot procedure for the synthesis of 3,5-disubstituted isoxazoles from acid chloride, terminal alkyne, and hydroxylamine hydrochloride catalyzed by Pd(PPh3)2Cl2/CuI has been developed. The coupling of acid c

Preparation of 3,5-disubstituted pyrazoles and isoxazoles from terminal alkynes, aldehydes, hydrazines, and hydroxylamine

The reaction of terminal alkynes with n-BuLi, and then with aldehydes, followed by the treatment with molecular iodine, and subsequently hydrazines or hydroxylamine provided the corresponding 3,5-disubstituted pyrazoles or isoxazoles in good yields with high regioselectivity, through the formations of propargyl secondary alkoxides and α-alkynyl ketones. The present reactions are one-pot preparation of 3,5-disubstituted pyrazoles from terminal alkynes, aldehydes, molecular iodine, and hydrazines, and 3,5-disubstituted isoxazoles from terminal alkynes, aldehydes, molecular iodine, and hydroxylamine.

Formation of 4-Benzamidoisoxazole Derivatives

The titled compounds (3) were synthesized by the reaction of nitrile oxides with 1-azirines and also the reaction of aliphatic nitro compounds with dibenzoylmethane derivatives in the presence of acetyl chloride and sodium methoxide.The structure of 3 was

Synthesis of New Isoxazoles from Isoxazolines, Chalkones, Chalkone Dibromides, Epoxides and Acetylated Ketoximes and Their Conversion into Novel Heterocycles

A convenient and easy conversion of 2-isoxazolines (II) to isoxazoles (V) via N-bromosuccinimide bromination and subsequent dehydrobromination with bases is described.The isoxazoles have also been synthesized from chalkones (I), chalkone dibromides (III)