208245-69-6

Basic information

• Product Name: tert-butyl 4-(methylthio)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(methylthio)piperidine-1-carboxylate;4-methylsulfanylpiperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(methylthio)-, 1,1-dimethylethyl ester
• CAS NO: 208245-69-6
• Molecular Formula: C11H21NO2S
• Molecular Weight: 231
• Mol File: 208245-69-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 313.192°C at 760 mmHg
• Flash Point: 143.213°C
• Appearance: /
• Density: 1.068g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-butyl 4-(methylthio)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(methylthio)piperidine-1-carboxylate(208245-69-6)
• EPA Substance Registry System: tert-butyl 4-(methylthio)piperidine-1-carboxylate(208245-69-6)

Safety Data

• Hazardous Substances Data: 208245-69-6(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(methylthio)piperidine-1-carboxylate is a chemical compound with the molecular formula C13H25NO2S. It is a derivative of piperidine and contains a tert-butyl group, a methylthio group, and a carboxylic ester group. tert-butyl 4-(methylthio)piperidine-1-carboxylate is commonly used in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. It has a wide range of applications, including as an intermediate for the synthesis of various drugs and as a reagent in organic chemistry reactions.

InChI:InChI=1/C11H21NO2S/c1-11(2,3)14-10(13)12-7-5-9(15-4)6-8-12/h9H,5-8H2,1-4H3

Upstream product

• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 208245-70-9 4-(methylthio)piperidine hydrochloride 
• 1190979-68-0 2-(4-(2-chloro-4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine 
• 479611-96-6 4-(methylsulfonyl)piperidine hydrochloride 
• 189205-49-0 4-methanesulfonylpiperidine-1-carboxylic acid tert-butyl ester 
• 767270-41-7 4-methylsulfanyl-piperidine 

Relevant articles and documents

COMPOUNDS WITH HIV MATURATION INHIBITORY ACTIVITY

The present invention relates to compounds characterized by having a structure according to the following Formula (I), or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or prevention of HIV.

Rational design of phosphoinositide 3-kinase inhibitors that exhibit selectivity over the phosphoinositide 3-kinase isoform

Of the four class I phosphoinositide 3-kinase (PI3K) isoforms, PI3K has justly received the most attention for its potential in cancer therapy. Herein we report our successful approaches to achieve PI3K vs PI3K selectivity for two chemical series. In the thienopyrimidine series of inhibitors, we propose that select ligands achieve selectivity derived from a hydrogen bonding interaction with Arg770 of PI3K that is not attained with the corresponding Lys777 of PI3K. In the benzoxepin series of inhibitors, the selectivity observed can be rationalized by the difference in electrostatic potential between the two isoforms in a given region rather than any specific interaction.

BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE

The invention is directed to Compounds of Formula (I): the invention provides compounds that inhibit, regulate, and/or modulate P13K and/or mTOR that are useful in the treatment of hyperproliferative diseases, such as cancer, in mammals. This invention al