20829-97-4

Usage

Uses

Used in Pharmaceutical Industry:
5-NITROISATOIC ANHYDRIDE, TECH. is used as a building block for the synthesis of various pharmaceuticals. Its reactivity allows it to participate in multiple chemical reactions, contributing to the development of new and effective medications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-NITROISATOIC ANHYDRIDE, TECH. is utilized as a precursor in the synthesis of agrochemicals. Its ability to undergo different chemical reactions aids in the production of compounds that help protect crops and enhance agricultural productivity.
Used in Dye and Pigment Synthesis:
5-NITROISATOIC ANHYDRIDE, TECH. is used as a precursor for the synthesis of dyes and pigments. Its involvement in various chemical reactions enables the creation of a wide range of colorants used in different industries, such as textiles, plastics, and printing inks.
Used in Organic Compound Synthesis:
5-NITROISATOIC ANHYDRIDE, TECH. is employed as a starting material in the synthesis of various organic compounds. Its reactivity and ability to participate in multiple chemical reactions make it a valuable component in the production of diverse organic molecules for various applications.

InChI:InChI=1/C8H4N2O5/c11-7-6-4(9-8(12)15-7)2-1-3-5(6)10(13)14/h1-3H,(H,9,12)

Upstream product

• 872266-38-1 2-azidocarbonyl-6-nitro-benzoic acid 
• 675575-44-7 2-ethoxycarbonylamino-6-nitro-benzoic acid 
• 603-12-3 2,6-dinitrobenzoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 50573-74-5 6-nitroanthranilic acid 
• 603-83-8 3-nitro-o-tolylamine 
• 381670-28-6 (2-methyl-3-nitro-phenyl)-carbamic acid ethyl ester 

Downstream Products

• 185305-73-1 (2-Amino-6-nitro-phenyl)-pyrrolidin-1-yl-methanone 
• 50573-74-5 6-nitroanthranilic acid 
• 99-09-2 3-nitro-aniline 
• 675575-44-7 2-ethoxycarbonylamino-6-nitro-benzoic acid 
• 185305-74-2 (2-Methoxy-piperidin-1-yl)-(2-nitro-phenyl)-methanone 
• 185305-78-6 (2-Allyl-piperidin-1-yl)-(2-nitro-phenyl)-methanone 
• 185305-80-0 (2-Allyl-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone 
• 185305-76-4 (2-Methoxy-pyrrolidin-1-yl)-(2-nitro-phenyl)-methanone 
• 185305-25-3 (2-Amino-phenyl)-(2-propyl-piperidin-1-yl)-methanone 
• 185305-62-8 (2-Amino-phenyl)-(2-propyl-pyrrolidin-1-yl)-methanone 
• 185305-27-5 (2-Allyl-piperidin-1-yl)-(2-amino-phenyl)-methanone 
• 185305-66-2 (2-Allyl-pyrrolidin-1-yl)-(2-amino-phenyl)-methanone 
• 185305-71-9 (2-Amino-6-nitro-phenyl)-piperidin-1-yl-methanone 

Relevant academic research and scientific papers

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

AUTOMATED RADIOSYNTHESIS

The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as FastlabTM. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.

4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES HAVING CCR3 ANTAGONISM

The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides 4,4-(disubstituted)piperidine derivatives represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C1-C6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.

Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders: Structure-Activity Relationship

Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The compounds were tested in mice for their inhibitory effects on disease development in the acute experimental autoimmune encephalomyelitis model and selected compounds in the beagle dog for induction of proinflammatory reaction. Structure-activity relationships are discussed. Compound 8c, laquinimod, showed improved potency and superior toxicological profile compared to the lead compound roquinimex (1b, Linomide) and was selected for clinical studies (currently in phase II).