603-12-3

Basic information

• Product Name: 2,6-DINITROBENZOIC ACID
• Synonyms: 2,6-DINITROBENZOIC ACID;RARECHEM AL BO 2374
• CAS NO: 603-12-3
• Molecular Formula: C₇H₄N₂O₆
• Molecular Weight: 212.12
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 603-12-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 202-206°C
• Boiling Point: 351.93°C (rough estimate)
• Flash Point: 179.2 °C
• Appearance: /
• Density: 1.7333 (rough estimate)
• Vapor Pressure: 5.78E-07mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• PKA: pK1:1.14 (25°C)
• Water Solubility: 16.10g/L(temperature not stated)
• CAS DataBase Reference: 2,6-DINITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DINITROBENZOIC ACID(603-12-3)
• EPA Substance Registry System: 2,6-DINITROBENZOIC ACID(603-12-3)

Safety Data

• Hazardous Substances Data: 603-12-3(Hazardous Substances Data)

Usage

Uses

2,6-Dinitrobenzoic Acid is a urinary metabolite of nitrotoluenes.

Purification Methods

Crystallise the acid from water. [Beilstein 9 II 279, 9 III 1778, 9 IV 1242.]

InChI:InChI=1/C7H4N2O6/c10-7(11)6-4(8(12)13)2-1-3-5(6)9(14)15/h1-3H,(H,10,11)

Upstream product

• 607-34-1 5-nitroquinoline 
• 606-20-2 2,6-dinitrotoluene 
• 606-22-4 2,6-dinitroaniline 
• 552-16-9 ortho-nitrobenzoic acid 
• 13985-56-3 2-ethyl-1,3-dinitrobenzene 
• 7697-37-2 nitric acid 
• 606-31-5 2,6-dinitrobenzaldehyde 
• 155593-11-6 (2,6-dinitro-phenyl)-acetonitrile 
• 702642-25-9 4-ethyl-3,5-dinitrobenzeneamine 
• 13985-60-9 2-ethyl-1,3,5-trinitrobenzene 
• 93213-74-2 2-(bromomethyl)-1,3-dinitrobenzene 
• 124-38-9 carbon dioxide 
• 4185-79-9 2-bromo-1,3-dinitrobenzene 

Downstream Products

• 42087-82-1 methyl 2,6-dinitrobenzoate 
• 35213-00-4 2,6-dinitrobenzonitrile 
• 73748-78-4 2,4-diacetylaminobenzoic acid 
• 43134-76-5 1-amino-3-acetylamino-6-carboxy-benzene 
• 99-65-0 meta-dinitrobenzene 
• 124-38-9 carbon dioxide 
• 108-45-2 m-phenylenediamine 
• 35572-79-3 5-chloro-2-methyl-1,3-dinitro-benzene 
• 77331-21-6 2,6-Dinitrobenzoyl N,N-bis<2-oxo-3-oxazolidinyl>phosphorodiamidate 
• 1585988-68-6 (R)-2-(2,6-dinitrobenzamido)propanoic acid 
• 1585988-58-4 (S)-2-(2,6-dinitrobenzamido)propanoic acid 
• 1585988-34-6 (R)-2-(2-amino-6-fluorobenzamido)propanoic acid 
• 1585988-56-2 2-(2,6-dinitrobenzamido)acetic acid 
• 1286792-32-2 ortho-[⁽¹⁸⁾F]flumazenil tert-butyl ester 

Relevant articles and documents

-

-

F-18 RADIOLABELED COMPOUNDS FOR DIAGNOSING AND MONITORING KIDNEY FUNCTION

The invention relates to 18F-labeled compounds of formula (I), hydrates, isomers, or pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions. The invention relates to the methods of diagnosing kidney function in humans by PET imaging.

Vicarious nucleophilic substitution: A dramatically shortened synthesis of 2-amino-6-nitrobenzoic acid labelled with carbon-14

Literature preparations of 2-amino-6-nitrobenzoic acid are usually based on phthalic anhydride. In order to make [benzene-14C(U)]-2-amino-6- nitrobenzoic acid, [benzene-14C(U)]-phthalic anhydride has to be prepared in multiple steps from [14C(U)]-benzene, resulting in an unacceptably lengthy 14-step synthesis. We have been able to develop a completely different method of synthesis, producing [benzene- 14C(U)]-2-amino-6-nitrobenzoic acid from [14C(U)]-benzene in just four steps with an overall radiochemical yield of 32%.