20834-60-0

Upstream product

• 83755-95-7 4,6-dibromo-4-t-butyl-2-methylcyclohexa-2,5-dienone 
• 95-48-7 ortho-cresol 
• 98-27-1 2-Methyl-4-t-butylphenol 
• 7726-95-6 bromine 

Downstream Products

• 55454-61-0 2-bromo-6-methyl-4-tert-butylphenoxytriphenylsilane 
• 609-22-3 2,4-dibromo-6-methylphenol 
• 55454-57-4 2-triphenylsilyl-4-tert-butyl-6-methylphenol 
• 83755-95-7 4,6-dibromo-4-t-butyl-2-methylcyclohexa-2,5-dienone 
• 76274-17-4 Acetic acid 5-bromo-3-tert-butyl-1-methyl-6-oxo-cyclohexa-2,4-dienyl ester 
• 6293-55-6 2-bromo-6-methyl-[1,4]benzoquinone 

Relevant academic research and scientific papers

PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR?, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.

OXIDATIVE COUPLING REACTION OF 2-HALOPHENOLS WITH K3Fe(CN)6 IN BENZENE SOLUTION

The oxidative coupling of twelve 2-halophenols (1a-1l) was carried out with K3Fe(CN)6 in benzene solution to obtain the corresponding dibenzofuran derivatives.However, only a small amount of the desired dibenzofurans such as 2,6-di-tert-butyl-8-methoxybenzofuran-1,4-quinone (9) and 4,8-di-tert-butyl-2,6-di-isopropyl-1-hydroxydibenzofuran (11) were obtained from 2-bromo-6-tert-butyl-4-methoxy- (1d) and 2-bromo-4-tert-butyl-6-isopropylphenol (1g), respectively.In the other cases, alternative type of products or tarry materials were formed.

Electrophilic Substitution with Rearrangement. Part 10. Some Products of Bromination of 2,4-Dimethylphenol and of 4-t-Butyl-2-methylphenol

The reaction of 2,4-dimethylphenol with bromine gives first 6-bromo-2,4-dimethylphenol, which according to the conditions of further bromination can give 4,6-dibromo-2,4-dimethylcyclohexa-2,5-dienone; a mixture of 5,6- with some 3,6-dibromo-2,4-dimethylphenol; 6-bromo-4-bromomethyl-2-methylphenol with none of the 2-bromomethyl-4-methyl isomer; or a mixture from which 6-bromo-2,4-bis(bromomethyl)phenol can be isolated.The corresponding dienone from 6-bromo-4-t-butyl-2-methylphenol reacts by more complex pathways, and the products include those of de-t-butylation.The probable mechanisms involved in these reactions are discussed.