20834-61-1

Basic information

• Product Name: 2-BROMO-4,6-DI-TERT-BUTYLPHENOL
• Synonyms: AKOS GLO-BB-408;2-BROMO-4,6-DI-TERT-BUTYLPHENOL;4-Bromo-2,6-di-tert-butyphenol;2,4-Bis(tert-butyl)-6-bromophenol;2,4-Bis(tert-butyl)-6-bromophenol 97%;2-Bromo-4,6-di-tert-butyphenol;2,4-Bis(tert-butyl)-6-bromophenol97%
• CAS NO: 20834-61-1
• Molecular Formula: C₁₄H₂₁BrO
• Molecular Weight: 285.22
• EINECS: -0
• Mol File: 20834-61-1.mol
• Article Data: 33

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 269.8°C at 760 mmHg
• Flash Point: 117°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 0.00429mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• PKA: 10.04±0.23(Predicted)
• BRN: 2100150
• CAS DataBase Reference: 2-BROMO-4,6-DI-TERT-BUTYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4,6-DI-TERT-BUTYLPHENOL(20834-61-1)
• EPA Substance Registry System: 2-BROMO-4,6-DI-TERT-BUTYLPHENOL(20834-61-1)

Safety Data

• Hazardous Substances Data: 20834-61-1(Hazardous Substances Data)

Usage

Uses

It is used in pharmaceutical intermediates and as medicine. When 2-Bromo-4,6-di-tert-butylphenol was treated with potassium ferricyanide in benzene 1,4-dihydro-4-bromo-2,4,6,8-tetra-tert-butyl-1-oxodibenzofuran was yielded with a small amount of 2,4,6,8-tetra-tert-butyldibenzofuran.

InChI:InChI=1/C14H21BrO/c1-13(2,3)9-7-10(14(4,5)6)12(16)11(15)8-9/h7-8,16H,1-6H3

Upstream product

• 732-26-3 2,4,6-tri-tert-butylphenoxol 
• 1988-75-6 4-bromo-2,4,6-tri-tert-butyl-2,5-cyclohexadiene-1-one 
• 96-76-4 2,4-di-tert-Butylphenol 

Downstream Products

• 75333-71-0 2-bromo-4,6-di-tert-butylphenoxyethyldimethylsilane 
• 75315-00-3 2-bromo-4,6-di-tert-butylphenoxytriethylsilane 
• 5920-84-3 2-bromo-4,6-di-tert-butylphenyl trimethylsilyl ether 
• 21099-16-1 2-Brom-6-tert.-butyl-1,4-benzochinon 
• 55793-26-5 1,2-di(tert-butyl)-1,2-diphenyl-diphosphine 
• 53925-65-8 (2,4-di-tert-butylphenoxy)trimethylsilane 
• 185509-22-2 4,6-di-tert-butyl-2-diphenylphosphinophenyl trimethylsilyl ether 
• 185509-32-4 (2-diphenylphosphanyl-4,6-di(tert-butyl))phenol 
• 185509-36-8 ((2,4-di-tert-butylphenyl)O)(C₆H₅)2P 
• 460048-35-5 1-(3,5-di-tert-butyl-2-hydroxyphenyl)-2,2,2-trifluoroethanone 
• 1044260-52-7 C₁₅H₂₃NO₂ 
• 19715-19-6 3,5-ditertbutyl salicylic acid 
• 95091-86-4 3,5-di-tert-butyl-2-hydroxybenzonitrile 

Relevant articles and documents

Cubane and step-form structures of dilithium bis(aryloxy)phosphines

The lithium complexes RP(3,5-tBu2C6H 2OLi)2(THF)4, where R = Ph or iPr, (R[OPO]Li2)2(THF)4, synthesized by reaction of the 2-bromo-4,6-di-tert-butylphenol with BuLi and the appropriate dichlorophosphine, possess solid state structures composed of lithium oxide tetragons arranged in a step-form or face sharing half-cubane arrangements. Incorporation of excess lithium aryloxide results in the formation of complexes that display an extended step-form structure, [Ph[OPO]Li 2(ArOLi)]2, or a distorted cubane arrangement of tetragons, [iPr[OPO]Li3Cl(ArOLi)](THF)3. The Royal Society of Chemistry.

Supported permethylindenyl titanium catalysts for the synthesis of disentangled ultra-high molecular weight polyethylene (: Dis UHMWPE)

Novel permethylindenyl-phenoxide (PHENI?) ansa-metallocene titanium complexes have been synthesised and immobilised on inorganic solid supports to afford highly effective catalysts for slurry-phase ethylene polymerisation. When supported on solid polymeth

Phosphasalalen Rare-Earth Complexes for the Polymerization of rac-Lactide and rac-β-Butyrolactone

A series of new phosphasalalen pro-ligands, analogues of salalen but with an iminophosphorane replacing the imine functionality, and their corresponding rare-earth alkoxide and siloxide complexes were synthesized. The multinuclear NMR spectra and X-ray diffraction analyses revealed that, for the tert-butoxide and ethoxide complexes, the resulting phosphasalalen rare-earth product was composed of a mononuclear alkoxide and a binuclear complex containing bridged alkoxo and hydroxo groups, while an analogous binuclear complex was isolated as the sole product for the siloxide complex. All the complexes could catalyze the heteroselective ring-opening polymerization (ROP) of rac-lactide (Pr up to 0.77) with high catalytic activities and a controlled polydispersity. Remarkably, the yttrium and lutetium phosphasalalen complexes could also efficiently catalyze the ROP of rac-β-butyrolactone to produce syndiotactic polymers (Pr up to 0.73) while their salalen analogues were inert, revealing the special effects of the iminophosphorane moiety. Detailed end-group analyses and kinetic investigations suggested that the alkoxo-hydroxo-bridged complexes maintained their binuclear structures in the polymerization.

COMPOSITIONS AND METHODS FOR IMMUNE MODULATION AND TREATMENT OF CANCER

The disclosure relates to rexinoids, including compounds of the Formula (I) and (II) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof. These rexinoids are useful for increasing PD-L1 in vivo, for treatment of cancer, and for inhibiting the onset of cancer.