20834-61-1

Usage

Uses

Used in Pharmaceutical Intermediates:
2-BROMO-4,6-DI-TERT-BUTYLPHENOL is used as a pharmaceutical intermediate for the synthesis of various medicinal compounds. Its unique structure allows for the creation of new drugs with potential therapeutic benefits.
Used in Medicine:
In the medical field, 2-BROMO-4,6-DI-TERT-BUTYLPHENOL is utilized in the development of pharmaceuticals due to its chemical properties that can be manipulated to produce desired effects in medications.
Used in Chemical Synthesis:
2-BROMO-4,6-DI-TERT-BUTYLPHENOL is used as a key component in the synthesis of complex organic molecules. For instance, when treated with potassium ferricyanide in benzene, it yields 1,4-dihydro-4-bromo-2,4,6,8-tetra-tert-butyl-1-oxodibenzofuran, along with a small amount of 2,4,6,8-tetra-tert-butyldibenzofuran. These synthesized compounds can have various applications in different industries, including the chemical and pharmaceutical sectors.

InChI:InChI=1/C14H21BrO/c1-13(2,3)9-7-10(14(4,5)6)12(16)11(15)8-9/h7-8,16H,1-6H3

Upstream product

• 96-76-4 2,4-di-tert-Butylphenol 
• 732-26-3 2,4,6-tri-tert-butylphenoxol 
• 1988-75-6 4-bromo-2,4,6-tri-tert-butyl-2,5-cyclohexadiene-1-one 

Downstream Products

• 5920-84-3 2-bromo-4,6-di-tert-butylphenyl trimethylsilyl ether 
• 21099-16-1 2-Brom-6-tert.-butyl-1,4-benzochinon 
• 55793-26-5 1,2-di(tert-butyl)-1,2-diphenyl-diphosphine 
• 53925-65-8 (2,4-di-tert-butylphenoxy)trimethylsilane 
• 185509-22-2 4,6-di-tert-butyl-2-diphenylphosphinophenyl trimethylsilyl ether 
• 185509-32-4 (2-diphenylphosphanyl-4,6-di(tert-butyl))phenol 
• 185509-36-8 ((2,4-di-tert-butylphenyl)O)(C₆H₅)2P 
• 185509-31-3 rac-4,6-di-tert-butyl-2-(tert-butyl(phenyl)phosphino)phenol 
• 185509-30-2 (2-isopropylphenyl(phenyl)phosphinyl)-4,6-di-tert-butylphenol 
• 140687-31-6 bis(3,5-di-tert-butyl-2-hydroxyphenyl)phenylphosphine(V) oxide 
• 217819-14-2 1-bromo-3,5-di-tert-butyl-2-methoxybenzene 
• 685506-95-0 2-(2,4,7-trimethylinden-1-yl)-4,6-di-tert-butylphenol 

Relevant academic research and scientific papers

Cubane and step-form structures of dilithium bis(aryloxy)phosphines

The lithium complexes RP(3,5-tBu2C6H 2OLi)2(THF)4, where R = Ph or iPr, (R[OPO]Li2)2(THF)4, synthesized by reaction of the 2-bromo-4,6-di-tert-butylphenol with BuLi and the appropriate dichlorophosphine, possess solid state structures composed of lithium oxide tetragons arranged in a step-form or face sharing half-cubane arrangements. Incorporation of excess lithium aryloxide results in the formation of complexes that display an extended step-form structure, [Ph[OPO]Li 2(ArOLi)]2, or a distorted cubane arrangement of tetragons, [iPr[OPO]Li3Cl(ArOLi)](THF)3. The Royal Society of Chemistry.

Copper(I) and copper(II) complexes possessing cross-linked imidazole-phenol ligands: Structures and dioxygen reactivity

Catalytic reduction of O2 to H2O, and coupling to membrane proton translocation, occurs at the heterobinuclear heme a3-CuB active site of cytochrome c oxidase. One of the CuB ligated histidines is cross-linked to a neighboring tyrosine (C-N bond; tyrosine C6 and histidine ε-nitrogen), and the protic residue of this cross-linked His-Tyr moiety is proposed to participate as both an electron and a proton donor in the catalytic dioxygen reduction event. To provide insight into the chemistry of such a moiety, we have synthesized and characterized tetra- and tridentate pyridylalkylamine chelate ligands {LN4OR and LN3OR (R = H or Me)}, which include an imidazole-phenol (or anisole) cross-link and their copper(I/II) complexes. [CuI(LN4OH)]B(C6F5)4 (1) reacts with dioxygen at -80 °C in THF, forming an unstable trans-μ-1,2-peroxodicopper(II)complex, which subsequently converts to a dimeric copper(II)-phenolate complex [{Cu(LN4O-)}2](B(C6F5)4)2 (5a). The close analogue [CuI(LN4OMe)]B(C6F5)4 (3) binds dioxygen reversibly at -80 °C in tetrahydrofuran. Stopped-flow kinetics of the reaction [CuI(LN3OH)]ClO4 (2) with O2 in CH2Cl2 indicate a steady formation of the purple dimeric product [{Cu(LN3O-)}2](ClO4)2 (5b), which has been analyzed in the temperature range from -40 to +20 °C, ΔH? = -9.6 (6) kJ mol-1, ΔS? = -168 (2) J mol-1 K-1 (k(-40°C) = 1.05(4) × 106 and k(+20°C) = 4.6(2) × 105 M-2 s-1). The X-ray crystal structures of 1, [CuII(LN3OH)(MeOH)(OClO3-)](ClO4) (4), 5a, and 5b are reported. Copyright

Supported permethylindenyl titanium catalysts for the synthesis of disentangled ultra-high molecular weight polyethylene (: Dis UHMWPE)

Novel permethylindenyl-phenoxide (PHENI?) ansa-metallocene titanium complexes have been synthesised and immobilised on inorganic solid supports to afford highly effective catalysts for slurry-phase ethylene polymerisation. When supported on solid polymeth

Ni, Pd, and Pt complexes of a tetradentate dianionic thiosemicarbazone-based O^N^N^S ligand

New tetradentate phenolate O^N^N^S thiosemicarbazone (TSC) ligands and their Ni(ii), Pd(ii) and Pt(ii) complexes were studied. The diamagnetic and square planar configured orange or red complexes show reversible reductive electrochemistry and in part reversible oxidative electrochemistry at very moderate potentials. DFT calculations show essentially pyridyl-imine centred lowest unoccupied molecular orbitals (LUMO) while the highest occupied molecular orbitals (HOMO) receive contributions from the phenolate moiety, the metal d orbitals and the TSC thiolate atom in keeping with UV-vis spectroelectrochemistry. DFT calculations in conjunction with IR spectra showed details of the molecular structures, the UV-vis absorptions were modelled through TD-DFT calculation with very high accuracy. UPS is fully consistent with UV-vis absorption and TD-DFT calculated data and shows decreasing HOMO-LUMO gaps along the series Pd > Pt > Ni.

Phosphasalalen Rare-Earth Complexes for the Polymerization of rac-Lactide and rac-β-Butyrolactone

A series of new phosphasalalen pro-ligands, analogues of salalen but with an iminophosphorane replacing the imine functionality, and their corresponding rare-earth alkoxide and siloxide complexes were synthesized. The multinuclear NMR spectra and X-ray diffraction analyses revealed that, for the tert-butoxide and ethoxide complexes, the resulting phosphasalalen rare-earth product was composed of a mononuclear alkoxide and a binuclear complex containing bridged alkoxo and hydroxo groups, while an analogous binuclear complex was isolated as the sole product for the siloxide complex. All the complexes could catalyze the heteroselective ring-opening polymerization (ROP) of rac-lactide (Pr up to 0.77) with high catalytic activities and a controlled polydispersity. Remarkably, the yttrium and lutetium phosphasalalen complexes could also efficiently catalyze the ROP of rac-β-butyrolactone to produce syndiotactic polymers (Pr up to 0.73) while their salalen analogues were inert, revealing the special effects of the iminophosphorane moiety. Detailed end-group analyses and kinetic investigations suggested that the alkoxo-hydroxo-bridged complexes maintained their binuclear structures in the polymerization.

Selective Bromination of β-Positions of Porphyrin by Self-Catalytic Behaviour of VOTPP: Facile Synthesis, Electrochemical Redox Properties and Catalytic Application

Oxidovanadium(IV) complex of β-octabromo-meso-tetraphenylporphyrin, {[VIVO(TPPBr8)], 2} was synthesized by self-catalytic oxidative bromination of meso-tetraphenylporphyrinatooxidovanadium(IV) {[VIVO(TPP), 1} in excellent yield under mild conditions at 25 °C and its structure was confirmed by single crystal X-ray study. UV-Vis and 1H NMR spectra further confirmed that the meso-phenyl rings are not brominated and thus emphasizes on the selectivity as well as synthetic importance of this catalytic method. In the presence of substrates e. g. phenol derivatives, 1 biomimics the vanadium bromoperoxidase (VBPO) enzyme and catalyses the oxidative bromination of substrates in water at 25 °C. Remarkably, 2 also catalyses the oxidative bromination of phenol derivatives under similar reaction conditions with very high turnover frequency (TOF) values (ca. 29 s?1) along with its recyclability. It was found that 2 showed superior catalytic performance as compared to 1 because of its electron deficient nature due to electron withdrawing bromo substituents and robust saddle shaped nonplanar structure (further supported by DFT studies).

COMPOSITIONS AND METHODS FOR IMMUNE MODULATION AND TREATMENT OF CANCER

The disclosure relates to rexinoids, including compounds of the Formula (I) and (II) or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof. These rexinoids are useful for increasing PD-L1 in vivo, for treatment of cancer, and for inhibiting the onset of cancer.

Biphenol compound as well as preparation method and application thereof

The invention discloses a biphenyl triphenol compound. The compound has a structure as shown in the following formula (I). The biphenyl triphenol compound provided by the invention is an important intermediate for synthesizing a tridentate phosphite ligand of a biphenyl frame, and plays an important role in hydroformylation reaction and industrial application thereof. The invention also provides preparation methods of various biphenol compounds, including an oxidative coupling method; the oxidative coupling method provided by the invention can be used for synthesizing the biphenol compounds inone step; and the method has the advantages of cheap and easily available catalyst, simple operation, good yield, low cost and large-scale preparation.

Biphenyltridentate phosphite ligand and preparation method and application thereof (by machine translation)

The invention discloses a biphenyl tridentate phosphite ligand and a preparation method and application thereof, wherein the biphenyltridentate phosphite ligand has the structure shown in a formula (I), and the ligand has extremely stable water oxygen. The catalyst is not easy to decompose and has good catalytic activity. (by machine translation)

A new bis-phenolate mesoionic carbene ligand for early transition metal chemistry

We report the synthesis of a new pincer-type triazolylidene ligand precursor H3L[Cl] with redox-active 3,5-di-tert-butylphenolate substituents on a multigram scale following a converging ten-step route. The potential of this new mesoionic carbe