208448-45-7Relevant academic research and scientific papers
A chemoselective, acid mediated conversion of amide acetal to oxazole: The key step in the synthesis of cardiovascular drug, ifetroban sodium
Swaminathan, Shankar,Singh, Ambarish K.,Li, Wen-Sen,Venit, John J.,Natalie Jr., Kenneth J.,Simpson, James H.,Weaver, Raymond E.,Silverberg, Lee J.
, p. 4769 - 4772 (1998)
The cyclization of acetal amide was carried out with trimethylsilyl trifluoromethanesulfonate, followed by elimination using sodium methoxide to give 2,5-disubstituted oxazole, thus completing a new route to the cardiovascular drug ifetroban sodium.
