Tetrahedron Letters p. 4769 - 4772 (1998)
Update date:2022-07-29
Topics:
Swaminathan, Shankar
Singh, Ambarish K.
Li, Wen-Sen
Venit, John J.
Natalie Jr., Kenneth J.
Simpson, James H.
Weaver, Raymond E.
Silverberg, Lee J.
The cyclization of acetal amide was carried out with trimethylsilyl trifluoromethanesulfonate, followed by elimination using sodium methoxide to give 2,5-disubstituted oxazole, thus completing a new route to the cardiovascular drug ifetroban sodium.
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(1998)Doi:10.1016/s0020-1693(97)06020-9
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(1998)
