A chemoselective, acid mediated conversion of amide acetal to oxazole: The key step in the synthesis of cardiovascular drug, ifetroban sodium

DOI: 10.1016/S0040-4039(98)00904-6

Source and publish data:

Tetrahedron Letters p. 4769 - 4772 (1998)

Update date:2022-07-29

Topics:

Authors:

Swaminathan, Shankar

Singh, Ambarish K.

Li, Wen-Sen

Venit, John J.

Natalie Jr., Kenneth J.

Simpson, James H.

Weaver, Raymond E.

Silverberg, Lee J.

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Article abstract of DOI:10.1016/S0040-4039(98)00904-6

The cyclization of acetal amide was carried out with trimethylsilyl trifluoromethanesulfonate, followed by elimination using sodium methoxide to give 2,5-disubstituted oxazole, thus completing a new route to the cardiovascular drug ifetroban sodium.

Full text of DOI:10.1016/S0040-4039(98)00904-6

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