208456-29-5

Upstream product

• 107-15-3 ethylenediamine 
• 217977-00-9 10,11-anhydro-2',4''-di-O-acetyl-12-O-(imidazol-1-ylcarbonyl)-6-O-methylerythromycin A 
• 152235-55-7 2',4''-di-O-acetyl-6-O-methylerythromycin A 
• 81103-11-9 clarithromycin 
• 213330-00-8 C₄₅H₇₇N₃O₁₅ 

Relevant academic research and scientific papers

Clarithromycin-adenine and related conjugates

Macrolide-nucleoside and macrolide-nucleobase conjugates (chimeras) have been synthesised by linking erythromycin A oxime derivatives and clarithromycin C11,C12-oxazolidinone derivatives with 3′-amino-3′-deoxythymidine or adenine through different spacers; clarithromycin-adenine conjugate 16a is the most active species against Micrococcus luteus.

Synthesis and antibacterial activity of the tricyclic Ketolides TE-802 and its analogs

The novel 6-O-methyl tricyclic ketolides TE-802 and its analogs were synthesized by two successive cyclization reactions, 11,12-cyclic carbamate formation by intramolecular Michael addition and 9,11-diazaheptene ring construction by intramolecular dehydration reaction. These new tricyclic ketolides exhibited good in vitro antibacterial activity against not only erythromycin-susceptible strains but also erythromycin-resistant Staphylococcus aureus and Streptococcus pneumoniae, which are problematic pathogens of nosocomial and community-acquired respiratory tract infections, respectively.