208458-78-0

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 1608-26-0 Hexamethylphosphorous triamide 
• 3348-44-5 bis(N,N-dimethylamino)chlorophosphine 

Downstream Products

• 119619-07-7 C₄₀H₄₃ClN₃O₇PS 
• 127088-96-4 C₅₀H₅₁Cl₂N₄O₁₃PS 
• 127088-90-8 O-(3'-O-acetylthymidin-5'-yl) O-(5'-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) phosphorodithioate 
• 127088-95-3 C₄₆H₅₀N₅O₁₃PS 
• 118149-25-0 O-5'-O-(Di-p-methoxytrityl)thymidin-3'-yl, O-3'-O-(acetyl)thymidin-5'-yl-phosphorodithioate 
• 127088-91-9 triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 118149-27-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] S-(2,4-dichlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 119619-08-8 O-(5'-O-(dimethoxytrityl)thymidin-3'-yl) S-(2,4-dichlorobenzyl) N,N-dimethyl thiophosphoramidite 
• 127088-88-4 O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-dimethylthiophosphoramidite 

Relevant academic research and scientific papers

Imidazo-oxazaphosphorines as precursors to chiral phosphite triesters

New bicyclic imidazo-oxazaphosphorines underwent a highly diastereoselective displacement of the imidazole moiety upon reaction with various alcohols, leading to chiral phosphite triesters as single diastereomers. The introduction of a nucleoside on this

Deoxyribonucleoside Phosphorodithioates. Preparation of Dinucleoside Phosphorodithioates from Nucleoside Thiophosphoramidites

A series of protected thymidine thiophosphoramidites have been prepared and their properties evaluated.Although less reactive than phosphoramidites, thiophosphoramidites with small N-substituents (methyl) are useful synthons for the preparation of nucleoside phosphorodithioates, as demonstrated by the preparation of a thymidine dimer.The coupling reactions are not as clean as those of the analogous phosphoramidites since the alkylthio group is somewhat labile.