212965-31-6Relevant academic research and scientific papers
Novel synthesis of chiral, enantiomerically pure thiodiglycols and diglycols
Christoffers, Jens,Roessler, Ulrich
, p. 2349 - 2357 (1998)
Natural α-hydroxy acids have been converted in a sequence of O- protection, reduction, O-activation, thioether and ether formation and deprotection to chiral, non-racemic β,β'-dihydroxy thioethers 1a, 1b and ether 1c. Overall yields are excellent (75%). In an attempt to synthesize the respective dihydroxy ether 1d derived from mandelic acid 1,3-dioxolane derivatives 7 were obtained.
