208459-94-3

Upstream product

• 21565-82-2 methyl pent-4-ynoate 
• 75056-76-7 1-iodo-2,5-dimethoxy-4-methylbenzene 

Downstream Products

• 208459-96-5 1,4-cyclohexadiene-1-pentanoic acid 4-methyl-3,6-dioxo methyl ester 
• 259674-47-0 1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester 
• 259674-48-1 5-(2,5-bis-aziridin-1-yl-4-methyl-3,6-dioxo-cyclohexa-1,4-dienyl)-pentanoic acid 
• 208459-95-4 benzenepentanoic acid 2,5-dimethoxy-4-methyl methyl ester 

Relevant academic research and scientific papers

Triplex-directed interstrand DNA cross-linking by diaziridinylquinone- oligonucleotide conjugates

Triplex-forming oligonucleotides (TFOs) bind in the major groove to specific double-helical DNA sequences and have been shown to inhibit the function of targeted genes. Diaziridinylquinones are bifunctional alkylating agents that can form interstrand cros