259674-47-0Relevant academic research and scientific papers
Triplex-directed interstrand DNA cross-linking by diaziridinylquinone- oligonucleotide conjugates
Reed, Michael W.,Wald, Ansel,Meyer, Rich B.
, p. 9729 - 9734 (2007/10/03)
Triplex-forming oligonucleotides (TFOs) bind in the major groove to specific double-helical DNA sequences and have been shown to inhibit the function of targeted genes. Diaziridinylquinones are bifunctional alkylating agents that can form interstrand cros
