208464-46-4

Basic information

• Product Name: (R)-5-bromo-3-[(N-methylpyrrolidin-2-yl)methyl]-1-benzoylindole
• Synonyms: (R)-5-bromo-3-[(N-methylpyrrolidin-2-yl)methyl]-1-benzoylindole
• CAS NO: 208464-46-4
• Molecular Weight: 397.315
• Mol File: 208464-46-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-5-bromo-3-[(N-methylpyrrolidin-2-yl)methyl]-1-benzoylindole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-bromo-3-[(N-methylpyrrolidin-2-yl)methyl]-1-benzoylindole(208464-46-4)
• EPA Substance Registry System: (R)-5-bromo-3-[(N-methylpyrrolidin-2-yl)methyl]-1-benzoylindole(208464-46-4)

Safety Data

• Hazardous Substances Data: 208464-46-4(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 143322-57-0 (R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole 
• 6404-31-5 Z-D-proline 
• 61350-62-7 N-benzyloxycarbonyl-D-proline acid chloride 
• 143322-56-9 (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole 

Downstream Products

• 208464-81-7 C₂₆H₂₈N₂O₂ 

Relevant articles and documents

5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS

Described herein are compounds selective for a 5-HT1D-like receptor, which have general formula (I), wherein A is selected from a six-membered, non-aromatic, optionally substituted carbocycle and a six-membered, non-aromatic, optionally substituted heterocycle having one or two heteroatoms selected from O, S, SO, SO2 and NR; R is selected from H and OH; n is 0 or 1 as permitted by chemical structure; R is selected from CRRCH2NRR or a group of formula (II), (III) or (IV); R is selected from H and benzoyl; R is selected from H, loweralkyl, benzyl, loweralkylcarbonyl, loweralkylaminocarbonyl; loweralkylaminothiocarbonyl, loweralkanoyl, loweralkylaminoimide and loweralkoxy-substituted loweralkylene; R and R are independently selected from H, loweralkoxy and hydroxy; R and R are independently selected from H and loweralkyl or R and R form an alkylene bridge which, together with the nitrogen atom to which they are attached, creates an optionally substituted 3- to 6-membered ring; ----- denotes a single or double bond; and R, R and R are independently selected from H and loweralkyl. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT1D-like receptor is implicated, such as migraine.

5-CYCLO INDOLE COMPOUNDS

Described herein are compounds selective for a 5-HT 1D-like receptor, which have the general formula: STR1 wherein A is selected from a six-membered, non-aromatic, optionally substituted carbocycle and a six-membered, non-aromatic, optionally substituted heterocycle having one or two heteroatoms selected from O, S, SO, SO 2 and N 4 ; R 1 is selected from H and OH;n is 0 or 1 as permited by chemical structure;R 2 is selected from CR 5 CR 6 CH. sub.2 NR 7 R 8 or a group of formula II, III or IV: STR2 R. sup.3 is selected from H and benzoyl; R 4 is selected from H, loweralkyl, benzyl, loweralkylcarbonyl, loweralkylaminocarbonyl, loweralkylaminothiocarbonyl, loweralkanoyl, loweralkylaminoimide and loweralkoxy-substituted loweralkylene; R 5 and R. sup.6 are independently selected from H, loweralkoxy and hydroxy;R 7 and R. sup.8 are independently selected from H and loweralkyl or R 7 and R. sup.8 form an alkylene bridge which, together with the nitrogen atom to which they are attached, creates an optionally substituted 3-to 6-membered ring; denotes a single or double bond; andR. sup.9, R. sup.10 and R. sup.11 are independently selected from H and loweralkyl. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT 1D-like receptor is implicated, such as migraine.