208465-07-0

Basic information

• Product Name: t-Butoxycarbonyl-4-Tributylstannyl-1,2,3,6-tetrahydropyridine
• Synonyms: t-Butoxycarbonyl-4-Tributylstannyl-1,2,3,6-tetrahydropyridine;tert-butyl 4-(tributylstannyl)-5,6-dihydropyridine-1(2H)-carboxylate;3,6-Dihydro-4-(tributylstannyl)-1(2h)-pyridinecarboxylic acid t-butyl ester;4-(Tributylstannyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(tributylstannyl)-3,6-dihydropyridine-1(2H)-carboxylate
• CAS NO: 208465-07-0
• Molecular Formula: C₂₂H₄₃NO₂Sn
• Molecular Weight: 472.29232
• Mol File: 208465-07-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 464.392 °C at 760 mmHg
• Flash Point: 234.656 °C
• Appearance: /
• PKA: -1.44±0.40(Predicted)
• CAS DataBase Reference: t-Butoxycarbonyl-4-Tributylstannyl-1,2,3,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: t-Butoxycarbonyl-4-Tributylstannyl-1,2,3,6-tetrahydropyridine(208465-07-0)
• EPA Substance Registry System: t-Butoxycarbonyl-4-Tributylstannyl-1,2,3,6-tetrahydropyridine(208465-07-0)

Safety Data

• Hazardous Substances Data: 208465-07-0(Hazardous Substances Data)

Usage

General Description

"T-Butoxycarbonyl-4-Tributylstannyl-1,2,3,6-tetrahydropyridine" is a complex organic compound containing multiple functional groups, including t-butoxycarbonyl, tributylstannyl and a tetrahydropyridine ring. These functional groups contribute to the properties and potential applications of the compound in various chemical synthesis contexts. As a stannylated compound, it may also be involved in Stille coupling reactions, which are commonly used in organic synthesis. Its exact properties, such as its physical form, melting point, boiling point, etc., would need to be established through laboratory examination and would be dependent on the purity and specific conditions. It is important to handle such chemicals safely due to potential risks associated with some of these functional groups, possibly including flammability, reactivity, and toxicity issues.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 688-73-3 tri-n-butyl-tin hydride 
• 253429-04-8 1-(t-butoxycarbonyl)-4-hydroxy-4-tributylstannyl piperidine 

Downstream Products

• 675109-71-4 3-(5-methyl-3-phenylisoxazol-4-yl)-8-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole 
• 138647-50-4 4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1394387-84-8 2-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)-N-((3-isopropylisoxazol-5-yl)methyl)ethanamine 
• 917755-88-5 2-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine 
• 1553930-00-9 2-(2-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)ethyl)iso-indoline-1,3-dione 
• 208465-04-7 (S)-5-(1-aza-1-tert-butoxycarbonylcyclohex-3-en-4-yl)-3-[(N-methylpyrrolidin-2-yl)methyl]-1-benzoylindole 
• 208465-05-8 5-(1-aza-1-tert-butoxycarbonylcyclohex-3-en-4-yl)-3-[2-(N,N-dimethylamino)ethyl]-1-benzoylindole 
• 677349-86-9 7-[1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]-5-(3,4-dimethoxybenzylamino)-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]pyrimidine 

Relevant articles and documents

Flow Photo-Nazarov Reactions of 2-Furyl Vinyl Ketones: Cyclizing a Class of Traditionally Unreactive Heteroaromatic Enones

Nazarov reactions of 2-furyl vinyl ketones and related heteroaromatic enones, to produce furan-fused cyclopentanones using a flow photochemical approach, are described. Compounds possessing this connectivity between heterocycle and ketone (2-furyl, 2-benzofuryl, 2-thiophene-yl, and 2-benzothiophene-yl) have traditionally proven difficult or impossible to cyclize with typical Br?nsted and Lewis acid mediated methods. Using mild flow photochemistry conditions and acetic acid (AcOH) or hexafluoroisopropanol (HFIP) as solvent, these compounds were found to cyclize in 45-97% yields, with typical UV exposure times of 3.4-6.8 min. In all cases, 2-furyl and 2-thiophene-yl enones cyclized, whereas 2-benzofuryl and 2-benzothiophene-yl enones exhibited divergent properties with reactivity patterns tied to the identity of the vinyl group. This report discloses the first photo-Nazarov reactions of tetrahydropyridine-substituted 2-furyl ketones, providing a direct approach to the corresponding fused heterocyclic motifs built around a central cyclopentanone. These motifs constitute the core structures of biologically active natural products, including the marine alkaloid nakadomarin A.

CHEMICAL COMPOUNDS

The use of a compound of formula I, Y is a single bond, C=O, C=S or S(O)m where m is 0, 1 or 2; the ring is a 6 membered oaromatic ring or is a 5 or 6 membered heteroaromatic ring; Z and Z' are =C- or -N- provided that both are not N; R1/

Piperidine derivatives as reuptake inhibitors

The present invention provides compounds of formula (I) and a method of inhibiting the reuptake of serotonin and antagonizing the serotonin receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula (I).