208642-91-5Relevant academic research and scientific papers
Oxyguanidines: Application to non-peptidic phenyl-based thrombin inhibitors
Tomczuk, Bruce,Lu, Tianbao,Soll, Richard M.,Fedde, Cynthia,Wang, Aihua,Murphy, Larry,Crysler, Carl,Dasgupta, Malini,Eisennagel, Stephen,Spurlino, John,Bone, Roger
, p. 1495 - 1498 (2007/10/03)
Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.
