208648-73-1

Upstream product

• 63128-51-8 5-(tert-butoxy)-5-oxopentanoic acid 
• 126-81-8 dimedone 

Downstream Products

• 208648-74-2 5-(4,4-dimethyl-2,6-dioxocyclohexylidene)-5-hydroxypentanoic acid 
• 338958-01-3 tert-butyl 5-(4-hydroxymethylanilino)-5-(4,4-dimethylcyclohexylidene-2,6-dioxo)pentanoate 

Relevant academic research and scientific papers

Versatile Dde-based primary amine linkers for solid phase synthesis

Linkers based on the Dale primary amine protecting strategy have been developed and their utility demonstrated in the solid phase synthesis of a naturally occurring spider toxin. The linkers are stable to both acid and base conditions and cleaved either with 2% v/v hydrazine hydrate or by transamination with a volatile primary alkylamine in a variety of organic solvents.

A Dde-based carboxy linker for solid-phase synthesis

The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employ