Tetrahedron Letters p. 3585 - 3588 (1998)
Update date:2022-08-05
Topics:
Chhabra, Siri Ram
Khan, Azra N.
Bycroft, Barrie W.
Linkers based on the Dale primary amine protecting strategy have been developed and their utility demonstrated in the solid phase synthesis of a naturally occurring spider toxin. The linkers are stable to both acid and base conditions and cleaved either with 2% v/v hydrazine hydrate or by transamination with a volatile primary alkylamine in a variety of organic solvents.
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