Versatile Dde-based primary amine linkers for solid phase synthesis

Article abstract of DOI:10.1016/S0040-4039(98)00555-3

Linkers based on the Dale primary amine protecting strategy have been developed and their utility demonstrated in the solid phase synthesis of a naturally occurring spider toxin. The linkers are stable to both acid and base conditions and cleaved either with 2% v/v hydrazine hydrate or by transamination with a volatile primary alkylamine in a variety of organic solvents.