20865-16-1Relevant academic research and scientific papers
Novel Biginelli-like three-component cyclocondensation reaction: Efficient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones
Wang, Zong-Ting,Xu, Li-Wen,Xia, Chun-Gu,Wang, Han-Qing
, p. 7951 - 7953 (2004)
Iron (III) catalyzed the three-component Biginelli-like cyclocondensation reaction efficiently in acetonitrile to afford the corresponding 5-unsubstituted 3,4-dihydropyrimidin-2-(1H)-ones in high yields. The first Biginelli-like reactions of urea, aldehyd
Iodotrimethylsilane-accelerated one-pot synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones: A novel procedure for the Biginelli-like cyclocondensation reaction at room temperature
Sabitha, Gowravaram,Reddy, Kusuma B.,Srinivas, Rangavajjula,Yadav, Jillu S.
, p. 2996 - 2999 (2005)
A novel Biginelli-like cyclocondensation reaction is efficiently catalyzed by iodotrimethylsilane (Me3SiI) in MeCN. The reaction proceeds at room temperature by a three-component one-pot condensation of ketones with aldehydes and urea to afford
FeCl3·6H2O/TMSBr-catalyzed rapid synthesis of dihydropyrimidinones and dihydropyrimidinethiones under microwave irradiation
Zhao, Fei,Jia, Xiuwen,Li, Pinyi,Zhao, Jingwei,Huang, Jun,Li, Honglian,Li, Lin
, (2017/09/25)
An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3 6H2O TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones.
