208655-63-4Relevant academic research and scientific papers
Synthesis of 5S-(1-oxoalkyl and aryl)2-pyrrolidinone derivatives
Deskus, Jeffrey,Fan, Dongping,Smith, Michael B.
, p. 1649 - 1659 (1998)
N-Benzyl pyroglutamate esters react with aryllithium reagents and methyllithium to give moderate to good yields of 5-(I-oxoaryl) or 5-(I- oxoalkyl)-2-pyrrolidinone derivatives. The reaction proceeds without racemization, but is accompanied by formation of 5-(I-hydroxy- l-alkyl)-2- pyrrolidinone derivatives. This reaction gives very poor yields of ketone products with most other alkyl organolithium reagents such as n-butyllithium. Grignard reagents react to give primarily the alcohol.
Palladium catalysed formal 6-endo-trig approaches to pumiliotoxin alkaloids: Interception of the elusive cyclopropyl intermediate
Feutren, Stephanie,McAlonan, Helena,Montgomery, David,Stevenson, Paul J.
, p. 1129 - 1137 (2007/10/03)
Intramolecular Heck cyclisation of (E)-vinyl bromides leads to indolizidines, related to pumiliotoxin alkaloids, in which the stereochemistry of the trisubstituted double bond undergoes inversion. A cyclopropyl intermediate, which is believed to be respon
