Synthetic Communications p. 1649 - 1659 (1998)
Update date:2022-07-30
Topics:
Deskus, Jeffrey
Fan, Dongping
Smith, Michael B.
N-Benzyl pyroglutamate esters react with aryllithium reagents and methyllithium to give moderate to good yields of 5-(I-oxoaryl) or 5-(I- oxoalkyl)-2-pyrrolidinone derivatives. The reaction proceeds without racemization, but is accompanied by formation of 5-(I-hydroxy- l-alkyl)-2- pyrrolidinone derivatives. This reaction gives very poor yields of ketone products with most other alkyl organolithium reagents such as n-butyllithium. Grignard reagents react to give primarily the alcohol.
View MoreNEW FORTUNE INDUSTRIAL CO.,LTD.
website:http://newfortune.lookchem.com/
Contact:+86-25-8645-9456
Address:C4-105 GREEN ISLAND FLOWER TOWN
Jinan Yijialian Economic and Trade Development Co., Ltd.
Contact:+86 0531-66729596
Address:jinan
Shanghai Norky Pharmaceutical Co., LTD.
website:http://www.norkypharm.com
Contact:86-21-61075300
Address:1165 Jiangning Road, Office 1502, Shanghai, China
Hangzhou MuSui Pharm-tech Co.,Ltd
Contact:+86 571 85154797
Address:Room C309, Jun Wei Center, No.10 Kangjing Road
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Doi:10.1039/a800271a
(1998)Doi:10.1021/ja01031a046
(1969)Doi:10.1016/s0020-1693(98)00150-9
(1998)Doi:10.1515/hc-2019-0015
(2019)Doi:10.14233/ajchem.2014.16000
(2014)Doi:10.1016/j.tet.2016.03.027
(2016)