208655-85-0Relevant academic research and scientific papers
A general synthetic method toward uridylylated picornavirus VPg proteins
Van der Heden van Noort, Gerbrand J.,Schein, Catherine H.,Overkleeft, Herman S.,Van der Marel, Gijsbert A.,Filippov, Dmitri V.
, p. 333 - 336 (2013)
Small proteins called viral protein genome-linked (VPg), attached to the 5′-end of the viral RNA genome are found as common structure in the large family of picornaviruses. The replication of these viruses is primed by this VPg protein linked to a single uridylyl residue. We report a general procedure to obtain such nucleoproteins employing a pre-uridylylated tyrosine building block in an on-line solid phase-based approach. Copyright 2013 European Peptide Society and John Wiley & Sons, Ltd. The replication of picornaviruses is primed by a small so-called VPg protein linked to a uridylyl residue. We report a general procedure to obtain such nucleoproteins employing a pre-uridylylated tyrosine building block in an on-line solid phase based approach.
Synthesis of a nucleopeptide fragment from poliovirus genome
Filippov, Dmitri,Kuyl-Yeheskiely, Esther,Van Der Marel, Gijs A.,Tesser, Godefridus I.,Van Boom, Jacques H.
, p. 3597 - 3600 (2007/10/03)
Condensation of a properly protected uridylylated nucleopeptide with a heptadecapeptide gives after one-step deprotection the target nucleopeptide H-Gly-Ala-Tyr(5pU)-Thr-Gly-Leu-Pro-Asn-Lys-Lys-Pro-Asn-Val-Pro-Thr-Ile-Arg- Thr-Ala-Lys-Val-Gln-OH.
