208706-12-1

Basic information

• Product Name: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
• Synonyms: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264;N-[(1R)-2-[[[(1S*,3R*)-3-(AMINOMETHYL)CYCLOHEXYL]METHYL]AMINO]-1-(1H-INDOL-3-YLMETHYL)-2-OXOETHYL]SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1'-CARBOXAMIDE;(1R,1'R,3'R/1R,1'S)-L-054,264;S,3'
• CAS NO: 208706-12-1
• Molecular Formula: C33H41N5O2
• Molecular Weight: 539.71
• Mol File: 208706-12-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Store at +4°C
• CAS DataBase Reference: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264(208706-12-1)
• EPA Substance Registry System: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264(208706-12-1)

Safety Data

• Hazardous Substances Data: 208706-12-1(Hazardous Substances Data)

Usage

Description

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective somatostatin sst2 receptor agonist, which is a compound that specifically targets and activates the somatostatin sst2 receptor. This receptor is often overexpressed in tumors, making it a potential therapeutic target for various applications.

Uses

Used in Pharmaceutical Industry:
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is used as a therapeutic agent for targeting tumors with overexpressed somatostatin receptors. Its application is based on its ability to selectively activate the somatostatin sst2 receptor, which can be used to study signaling pathways related to the receptor and potentially develop targeted cancer treatments.
Used in Research and Development:
In the field of research and development, (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 serves as a valuable tool for studying the role of somatostatin receptors in various biological processes. By selectively activating the sst2 receptor, researchers can gain insights into the receptor's function and its potential as a therapeutic target for cancer and other diseases.
Used in Drug Delivery Systems:
Similar to gallotannin, (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can also benefit from novel drug delivery systems to enhance its applications and efficacy against cancer cells. Utilizing carriers such as organic and metallic nanoparticles can improve the delivery, bioavailability, and therapeutic outcomes of this selective somatostatin sst2 receptor agonist.

Biological Activity

Potent and selective somatostatin sst 2 receptor agonist (K i values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst 2 , sst 1 , sst 4 , sst 3 and sst 5 receptors respectively).

Upstream product

• 4299-70-1 D-Tryptophan methyl ester 
• 208705-94-6 C₂₆H₂₇N₃O₃ 
• 208705-95-7 C₂₅H₂₅N₃O₃ 
• 208705-97-9 (1R,3S)-3-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 
• 145149-55-9 3-{[(tert-butoxycarbonyl)amino]methyl}cyclohexanecarboxylic acid 
• 223771-35-5 Methanesulfonic acid (1R,3S)-3-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl ester 
• 208706-01-8 ((1S,3R)-3-Azidomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester 
• 208706-02-9 ((1S,3R)-3-Aminomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester 
• 208706-00-7 ((1S,3R)-3-Hydroxymethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester 
• 117445-22-4 3-(tert-butoxycarbonylamino-methyl)benzoic acid 
• 33042-66-9 spiro[indene-1,4'-piperidine] 
• 2393-20-6 3-aminomethylbenzoic acid 
• 1877-72-1 3-Cyanobenzoic acid 

Relevant articles and documents

Spiro [1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists [1]

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