208709-15-3

Upstream product

• 276697-21-3 (2R,3S,4S)-2-acetoxymethyl-4-(N,N-dimethyl,N-oxy)aminomethyl-3-benzoyloxy-1-tert-butoxycarbonylpyrrolidine 
• 276697-19-9 (2R,3S,4S)-2-acetoxymethyl-4-(N,N-dimethyl)aminomethyl-3-benzoyloxy-1-tert-butoxycarbonylpyrrolidine 
• 276697-23-5 (2R,3S)-2-acetoxymethyl-3-benzoyloxy-1-tert-butoxycarbonyl-4-exo-methylenepyrrolidine 
• 98-88-4 benzoyl chloride 
• 276697-25-7 (2R,3S)-3-benzoyloxy-1-tert-butoxycarbonyl-2-hydroxymethyl-4-exo-methylenepyrrolidine 
• 208711-86-8 (2R,3S)-2-(1-Ethoxy-ethoxymethyl)-3,5-dihydroxy-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 208709-17-5 (2R,3S,4S)-1-tert-butoxycarbonyl-3-benzoyloxy-4-methylpyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Diastereoselective synthesis of (2S,3S,4S)-3-hydroxy-4-methylproline, a common constituent of several antifungal cyclopeptides

(2S,3S,4S)-3-Hydroxy-4-methylproline 2 was synthesized from unsaturated γ-lactams 4 and 5 derived from (S)-pyroglutaminol. Starting from 5, haplophilic effect in the hydrogenation of a 4-exo-methylenic intermediate improved the diastereoselectivity of the synthesis, which was achieved in 19% yield. (C) 2000 Elsevier Science Ltd.

Synthesis of the nonproteinogenic amino acid (2s,3s,4s)-3-hydroxy-4- methylproline, a constituent of echinocandins

An enantioselective synthesis of the unusual 3,4-disubstituted proline 2, a constituent of antifungal echinocandins, has been achieved through 1,3- dipolar cycloaddition of N-methylnitrone to the α,β-unsaturated lactam 4 derived from (S)-pyroglutaminol.