20871-11-8Relevant academic research and scientific papers
The Remarkable Effect of Halogen Substitution on the Membrane Transport of Fluorescent Molecules in Living Cells
Ungati, Harinarayana,Govindaraj, Vijayakumar,Mugesh, Govindasamy
, p. 8989 - 8993 (2018)
Small-molecule-based fluorescent probes have become important tools in biology for sensing and imaging applications. However, the biological applications of many of the fluorescent molecules are hampered by low cellular uptake and high toxicity. In this paper, we show for the first time that the introduction of halogen atoms enhances the cellular uptake of fluorescent molecules and the nature of halogen atoms plays a crucial role in the plasma membrane transport in mammalian cells. The remarkably higher uptake of iodinated compounds compared to that of their chloro or bromo analogues suggests that the strong halogen bonding ability of iodine atoms may play an important role in the membrane transport. This study provides a novel strategy for the transport of fluorescent molecules across the plasma membrane in living cells.
Synthesis and spectral properties of 4-amino-and 4-acetylamino-N- arylnaphthalimides containing electron-donating groups in the N-aryl substituent
Panchenko,Fedorova,Perevalov,Jonusauskas,Fedorov
experimental part, p. 1233 - 1240 (2010/10/04)
A method for the synthesis of N-aryl-substituted 4-amino-and 4-acetylaminonaphthalimide derivatives with mono-and dialkoxy groups or a 15-crown-5 moiety in the N-aryl substituent is described. The introduction of electron-donating alkoxy groups into the benzene ring of the N-aryl fragment results in fluorescence quenching of the naphthalimide chromophore, which is most pronounced in the spectra of N-acetyl derivatives. The photophysical properties of the synthesized 4-amino-and 4-acetylaminonaphthalimides depend on the solvent polarity and its specific solvating ability due to H-bonding. The crown-containing compounds are promising fluorescent chemosensors for metal cations. ; 2009 Springer Science+Business Media, Inc.
Thermochromic rylene dyes
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, (2008/06/13)
The invention relates to rylene dyes of the general formula (I), wherein the variables have the following meanings: R represents hydrogen; optionally substituted C1-C30alkyl-C5-C8-cycloalkyl, aryl or hetaryl; R′ represents optionally substituted C2-C30alkyl or C5-C8cycloalkyl, substituted methyl; and n is 0 or 1. The invention also relates to the preparation and use of said dyes for coloring highly molecular organic and inorganic materials and to 9-amino-perylene-3,4-dicarboxylic acid imides (Va) as their intermediate products.
