20874-52-6 Usage
Description
Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.
Uses
Different sources of media describe the Uses of 20874-52-6 differently. You can refer to the following data:
1. Saikosaponin d (SSd) is an important active component of Bupleurum scorzonerifolium Willd., a traditional Chinese medicinal herb. Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.
2. Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.
Biological Activity
Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.
Clinical claims and research
We have previously identified a small-molecule, saikosaponin-d (Ssd), that exhibits anti-inflammatory effect via the suppression of NF-κB, NF-AT and AP-1 signaling. We recently showed that Ssd potentiated the anti-cancer potency of TNF-α through NF-κB inhibition. Ssd is one of the major triterpenoid saponins derived from Bupleurum falcatum L. (Umbelliferae), which is commonly prescribed for inflammatory and infectious diseases, and its active component Ssd was reported to have immuno-modulatory, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer activities.
Check Digit Verification of cas no
The CAS Registry Mumber 20874-52-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,8,7 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 20874-52:
(7*2)+(6*0)+(5*8)+(4*7)+(3*4)+(2*5)+(1*2)=106
106 % 10 = 6
So 20874-52-6 is a valid CAS Registry Number.
InChI:InChI=1/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26-,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1
20874-52-6Relevant articles and documents
Novel Cleavage of the Glycosidic Bond of Saponins in Alcoholic Alkali Metal Solution containing a Trace of Water
Ogihara, Yukio,Nose, Mitsuhiko
, p. 1417 (2007/10/02)
Treatment of saikosaponin c (8) with alcoholic alkali metal solution containing a trace of water afforded the sapogenin saikogenin E and three new partially hydrolysed prosapogenins in satisfactory yield.
