20875-63-2

Upstream product

• 51686-52-3 4-(2,3,4-trimethoxy-phenyl)-butyric acid 
• 634-36-6 1,2,3-trimethoxybenzene 
• 102222-55-9 ethyl 4-oxo-4-(2,3,4-trimethoxyphenyl)butanoate 
• 63213-41-2 4-oxo-4-(2,3,4-trimethoxyphenyl)butanoic acid 
• 51686-50-1 methyl 3-(2,3,4-trimethoxybenzoyl)propionate 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 102222-59-3 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin 
• 87797-21-5 1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin 
• 111859-59-7 2-bromo-5,6,7-trimethoxy-1-tetralone 

Relevant academic research and scientific papers

Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents

A series of new benzylideneindanone derivatives were designed, synthesized and evaluated as antitumor agents. Structure-activity relationship (SAR) studies showed that derivatives with 4,5,6-trimethoxyl on an indanone moiety displayed good anti-proliferative activities. Especially, compound 5a demonstrated the most potent inhibitory activity, with GI50 values from 0.172 to 0.57 μM for five kinds of cancer cell lines. Further investigation showed that 5a could inhibit microtubule polymerization and thus induce G2/M phase arrest and apoptosis in A549 cells. Our findings revealed the benzylideneindanone moiety as a new attractive scaffold for mitosis-targeting drug discovery.

Combretastatin analogs with tubulin binding activity

Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

Novel conformationally restricted tetracyclic analogs of δ8- tetrahydrocannabinol

Novel analogs of (-)-Δ8-tetrahydrocannabinol (Δ8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synt

An approach to the biomimetic synthesis of aryltetralin lignans

The BF3 catalysed cyclisation of 3-arylpropyl substituted quinone-methide ketals affords a mild, biomimetic route to aryltetralins. 1H- and 13C-NMR spectra of the products are reported.