51686-50-1

Upstream product

• 3878-55-5 methyl hydrogen succinate 
• 634-36-6 1,2,3-trimethoxybenzene 
• 108-30-5 succinic acid anhydride 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 63213-41-2 4-oxo-4-(2,3,4-trimethoxyphenyl)butanoic acid 
• 51686-51-2 methyl 4-(2,3,4-trimethoxyphenyl)butanoate 
• 74994-52-8 Acetic acid 1-[2-(4-methoxy-phenyl)-ethyl]-5-(2,3,4-trimethoxy-phenyl)-pentyl ester 
• 74882-24-9 1-(4-Methoxy-phenyl)-7-(2,3,4-trimethoxy-phenyl)-heptan-3-one 
• 74994-46-0 (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol 
• 56438-60-9 2-[2-(4-methoxyphenyl)ethyl]-1,3-dithiane 
• 74882-28-3 2-[2-(4-Methoxy-phenyl)-ethyl]-2-[4-(2,3,4-trimethoxy-phenyl)-butyl]-[1,3]dithiane 
• 74882-11-4 Toluene-4-sulfonic acid 4-(2,3,4-trimethoxy-phenyl)-butyl ester 
• 74882-21-6 1-(2,3,4-trimethoxyphenyl)butane 
• 74882-10-3 4-(2,3,4-trimethoxyphenyl)-1-bromobutane 
• 74882-09-0 4-(2,3,4-trimethoxyphenyl)butan-1-ol 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 20401-88-1 3-(4-methoxyphenyl)propional 
• 74882-22-7 C₂₆H₃₈O₆ 

Relevant academic research and scientific papers

Novel conformationally restricted tetracyclic analogs of δ8- tetrahydrocannabinol

Novel analogs of (-)-Δ8-tetrahydrocannabinol (Δ8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synt

Combretastatin analogs with tubulin binding activity

Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

Methods for the Construction of Linear 1,7-Diarylheptanoids; Synthesis of Di-O-methylcentrolobol and Precursors (Synthetic and Biosynthetic) to the meta,meta-Bridged Biphenyls Myricanol and Myricanone

1,7-diarylheptanoids are a varied natural product class in which 'linear' types appear to be biosynthetic precursors to macro(carbo)cyclic (3), macro(oxa)cyclic (4), and condensed polycyclic (5) examples.Various methods (suitable for radiolabelling) are described for constructing 'linear' diarylheptanoids, including Grignard couplings (employing activated magnesium) with arylpropanals and oxazonium salts (11a), (11h), (15a), and (15b)> and dithian alkylation (15c)>.Alkyl-lithium treatment of the benzyloxydithian (19b) gave 1,2,3-triphenylcyclopropane.Syntheses via trialkylcyanoborates were frustrated by disproportionation of the intermediate trialkylboranes.The diarylheptanoids synthesised (11a-h) and (15a-e) include synthetic and biosynthetic precursors to meta,meta-bridged biphenyls and related macrocyclic ethers.