2088-07-5Relevant articles and documents
CHEMISTRY OF SINGLET OXYGEN. PART 44: MECHANISM OF PHOTOOXIDATION OF 2,5-DIMETHYLHEXA-2,4-DIENE AND 2-METHYL-2-PENTENE.
Manring,Foote
, p. 4710 - 4717 (1983)
Solvent and temperature effects on the singlet oxygen oxidations of 2,6-dimethyl-2,4-hexadiene (DMHD) and 2-methyl-2-pentene (2M2P) are studied. It is concluded that the initial interaction between 2M2P and **1O//2 (which gives only ene products) and that between DMHD and **1O//2 (which gives ene products, dioxetane, and nonreactive quenching) are identical. It is also suggested that the quenching path for DMHD could involve formation of an intermediate zwitterion or 1,4-biradical, which undergoes intersystem crossing and decays to ground-state oxygen and DMHD.
Chromium-Catalyzed Production of Diols From Olefins
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Paragraph 0111, (2021/03/19)
Processes for converting an olefin reactant into a diol compound are disclosed, and these processes include the steps of contacting the olefin reactant and a supported chromium catalyst comprising chromium in a hexavalent oxidation state to reduce at least a portion of the supported chromium catalyst to form a reduced chromium catalyst, and hydrolyzing the reduced chromium catalyst to form a reaction product comprising the diol compound. While being contacted, the olefin reactant and the supported chromium catalyst can be irradiated with a light beam at a wavelength in the UV-visible spectrum. Optionally, these processes can further comprise a step of calcining at least a portion of the reduced chromium catalyst to regenerate the supported chromium catalyst.
Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics
Hogan, Philip C.,Chen, Chi-Li,Mulvihill, Kristen M.,Lawrence, Jonathan F.,Moorhead, Eric,Rickmeier, Jens,Myers, Andrew G.
, p. 318 - 325 (2018/03/21)
Key building blocks for the production of fully synthetic macrolides have been scaled-up in first time pilot plant and kilo-lab campaigns. These building blocks have supported the discovery of new macrolide antibiotics as well as ongoing preclinical studies.
Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxypentan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics
Seiple, Ian B.,Hog, Daniel T.,Myers, Andrew G.
supporting information, p. 57 - 60 (2015/12/26)
Methacrolein is transformed in three steps to (R)-3-tert-butyldiphenylsilyloxypentan-2-one or (R)-3-tert-butyldimethylsilyloxypentan-2-one, compounds which serve as building blocks for the construction of macrolide antibiotics. The route is practical, highly enantioselective, and easily scaled.
