208844-41-1

Basic information

• Product Name: (Z)-N-(3-methoxybenzyl)-5-ethylidene-2-pyrrolidinone
• Synonyms: (Z)-N-(3-methoxybenzyl)-5-ethylidene-2-pyrrolidinone
• CAS NO: 208844-41-1
• Molecular Weight: 231.294
• Mol File: 208844-41-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-N-(3-methoxybenzyl)-5-ethylidene-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-(3-methoxybenzyl)-5-ethylidene-2-pyrrolidinone(208844-41-1)
• EPA Substance Registry System: (Z)-N-(3-methoxybenzyl)-5-ethylidene-2-pyrrolidinone(208844-41-1)

Safety Data

• Hazardous Substances Data: 208844-41-1(Hazardous Substances Data)

Upstream product

• 208844-33-1 N-(3-methoxybenzyl)-4-hexynamide 
• 928-93-8 4-hexyn-1-ol 
• 41143-12-8 hex-4-ynoic acid 
• 61362-77-4 5-[tert-butyldimethylsilyloxy]pent-1-yne 
• 132645-60-4 tert-butyl(hex-4-yn-1-yloxy)dimethylsilane 

Downstream Products

• 321309-84-6 N-(3-methoxybenzyl)-5-(1-hydroxyethyl)-5-methoxy-2-pyrrolidinone 
• 321309-85-7 N-(3-methoxybenzyl)-5-hydroxy-5-(1-hydroxyethyl)-2-pyrrolidinone 

Relevant articles and documents

Intramolecular cyclization of β-alkynylpropanamides to γ-alkylidene- γ-butyrolactams

A general method for the base-catalized intramolecular cyclization of β-alkynylpropanamides 1 to γ-alkylidene-γ-butyrolactames 2 (and 3) was established. Reactions of β-alkynylamides 1c-h, possessing alkyl groups at the terminal acetylenes, in the presence of a catalytic amount of LiN(TMS)2/AgOTf (= 2:1) in toluene gave exclusively (Z)-alkylidenelactames 2c-h in good yields.