321309-85-7

Basic information

• Product Name: N-(3-methoxybenzyl)-5-hydroxy-5-(1-hydroxyethyl)-2-pyrrolidinone
• Synonyms: N-(3-methoxybenzyl)-5-hydroxy-5-(1-hydroxyethyl)-2-pyrrolidinone
• CAS NO: 321309-85-7
• Molecular Weight: 265.309
• Mol File: 321309-85-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-methoxybenzyl)-5-hydroxy-5-(1-hydroxyethyl)-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methoxybenzyl)-5-hydroxy-5-(1-hydroxyethyl)-2-pyrrolidinone(321309-85-7)
• EPA Substance Registry System: N-(3-methoxybenzyl)-5-hydroxy-5-(1-hydroxyethyl)-2-pyrrolidinone(321309-85-7)

Safety Data

• Hazardous Substances Data: 321309-85-7(Hazardous Substances Data)

Upstream product

• 208844-41-1 (Z)-N-(3-methoxybenzyl)-5-ethylidene-2-pyrrolidinone 
• 208844-33-1 N-(3-methoxybenzyl)-4-hexynamide 
• 132645-60-4 tert-butyl(hex-4-yn-1-yloxy)dimethylsilane 
• 61362-77-4 5-[tert-butyldimethylsilyloxy]pent-1-yne 
• 41143-12-8 hex-4-ynoic acid 
• 928-93-8 4-hexyn-1-ol 

Relevant articles and documents

Stereoselective synthesis of 5-(1-hydroxyalkyl)-2-pyrrolidinones utilizing oxidation of 5-alkylidene-2-pyrrolidinones to acyliminium ion precursors

A general method was devised for the LiN(TMS)2/AgOTf (=2:1)-catalyzed intramolecular (5-exo-dig) cyclization of β-alkynylamides 1 possessing alkyl, aryl or no functional groups at the terminal alkynes, to 5-alkylidene-2-pyrrolidinones 2. These 5-alkylidene-2-pyrrolidinones were oxidized to the diol-type alkoxylactams 3 by dimethyldioxirane (DMD) or mCPBA in MeOH. These alkoxylactams are useful as tertiary N-acyliminium ion precursors for the synthesis of threo-5-(1-hydroxyalkyl)-2-pyrrolidinone derivatives 5. (C) 2000 Elsevier Science Ltd.