208844-53-5Relevant academic research and scientific papers
A novel phenylpyrrolidine derivative: Synthesis and effect on cognitive functions in rats with experimental ishemic stroke
Baukov, Yuri I.,Borisevich, Sophia S.,Borozdenko, Denis A.,Chekhonin, Vladimir P.,Cherkashova, Elvira A.,Ezdoglian, Aiarpi A.,Golubev, Yaroslav V.,Gonchar, Darya I.,Gubskiy, Ilya L.,Gubsky, Leonid V.,Gureev, Maxim A.,Kiseleva, Nina M.,Lagunin, Alexey A.,Lyakhmun, Dmitri N.,Namestnikova, Daria D.,Negrebetsky, Vadim V.,Shagina, Anastasia D.,Shmigol, Tatiana A.,Tarasenko, Dmitri V.
, (2021/10/20)
We performed an in silico, in vitro, and in vivo assessment of a potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (compound 1) as a potential prodrug for cognitive function improvement in ischemic brain injury. Using in silico meth
Silyl Route of Lactam Alkylation in Syntheses of Lactamodipeptide Amides
Shipov,Kramarova,Kalashnikova,Besova,Baukov
, p. 1736 - 1741 (2007/10/03)
A general route to lactamodipeptide amides is proposed, based on reaction of N-trimethylsilyl-lactams with ethoxycarbonylmethyl chloroacetate, followed by reaction of the resulting ethoxycarbonylmethyl esters of lactamoacetic acids with esters of amino ac
Lactam-1-acetic acid carbalkoxymethyl esters and method for preparing same
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, (2008/06/13)
The present invention relates to organic chemistry. Lactam-1-acetic acid carbalkoxymethyl esters have the following general formula: STR1 wherein with R=H, n=1 or 3; with R=phenyl, n=1; R1 is an alkyl. A method for preparing said compounds comprises reacting lactams of the general formula: STR2 wherein with R=H, n=1 or 3, with R=phenyl n=1, with an alkali in a medium of aprotic solvents at a temperature of from 70° to 130° C., followed by the addition of an alkyl ester of a monohalcacetic acid to the resulting mixture and isolation of the desired product. The compounds according to the present invention are intermediate products in the synthesis of known biologically active substances.
