208932-18-7Relevant academic research and scientific papers
Application of enantiopure templated azomethine ylids to β-hydroxy-α- amino acid synthesis
Alker, David,Hamblett, Giles,Harwood, Laurence M.,Robertson, Sarah M.,Watkin, David J.,Williams, C. Eleri
, p. 6089 - 6098 (2007/10/03)
Chiral stabilised azomethine ylids derived from the reaction of (5S)-5- phenylmorpholin-2-one (1) with aldehydes undergo efficient and highly diastereocontrolled cycloaddition with a second molecule of aldehyde to furnish products (2) which may be converted into enantiomerically pure threo (2S,3R) β-hydroxy-α-amino acids (3) in excellent yield.
