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10148-69-3

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10148-69-3 Usage

Description

(2S,3R)-2-AMINO-3-HYDROXY-HEXANOIC ACID, also known as (2S,3R)-3-Hydroxynorleucine, is an organic compound with the molecular formula C6H13NO3. It is a chiral molecule with specific stereochemistry at the 2nd and 3rd carbon atoms, denoted by the (2S,3R) configuration. (2S,3R)-2-AMINO-3-HYDROXY-HEXANOIC ACID serves as a crucial intermediate in the synthesis of various pharmaceuticals due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
(2S,3R)-2-AMINO-3-HYDROXY-HEXANOIC ACID is used as an intermediate for the synthesis of antiviral and antihypertensive drugs. Its unique structure allows for the development of medications that can effectively target viral replication and regulate blood pressure, providing therapeutic benefits for patients suffering from these conditions.
Used in Antiviral Applications:
(2S,3R)-2-AMINO-3-HYDROXY-HEXANOIC ACID is used as a key component in the development of antiviral drugs. Its incorporation into the drug molecules can enhance their ability to inhibit viral replication, making it a valuable asset in the fight against viral infections.
Used in Antihypertensive Applications:
In the field of cardiovascular health, (2S,3R)-2-AMINO-3-HYDROXY-HEXANOIC ACID is used as a building block for antihypertensive medications. Its presence in these drugs can help regulate blood pressure and reduce the risk of hypertension-related complications.

Check Digit Verification of cas no

The CAS Registry Mumber 10148-69-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,4 and 8 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10148-69:
(7*1)+(6*0)+(5*1)+(4*4)+(3*8)+(2*6)+(1*9)=73
73 % 10 = 3
So 10148-69-3 is a valid CAS Registry Number.

10148-69-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3R)-2-amino-3-hydroxyhexanoic acid

1.2 Other means of identification

Product number -
Other names (+-)-erythro-2-amino-3-hydroxy-hexanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10148-69-3 SDS

10148-69-3Relevant articles and documents

Modular Chemoenzymatic Synthesis of GE81112 B1 and Related Analogues Enables Elucidation of Its Key Pharmacophores

Zwick, Christian R.,Sosa, Max B.,Renata, Hans

supporting information, p. 1673 - 1679 (2021/01/25)

The GE81112 complex has garnered much interest due to its broad antimicrobial properties and unique ability to inhibit bacterial translation initiation. Herein we report the use of a chemoenzymatic strategy to complete the first total synthesis of GE81112 B1. By pairing iron and α-ketoglutarate dependent hydroxylases found in GE81112 biosynthesis with traditional synthetic methodology, we were able to access the natural product in 11 steps (longest linear sequence). Following this strategy, 10 GE81112 B1 analogues were synthesized, allowing for identification of its key pharmacophores. A key feature of our medicinal chemistry effort is the incorporation of additional biocatalytic hydroxylations in modular analogue synthesis to rapidly enable exploration of relevant chemical space.

Application of enantiopure templated azomethine ylids to β-hydroxy-α- amino acid synthesis

Alker, David,Hamblett, Giles,Harwood, Laurence M.,Robertson, Sarah M.,Watkin, David J.,Williams, C. Eleri

, p. 6089 - 6098 (2007/10/03)

Chiral stabilised azomethine ylids derived from the reaction of (5S)-5- phenylmorpholin-2-one (1) with aldehydes undergo efficient and highly diastereocontrolled cycloaddition with a second molecule of aldehyde to furnish products (2) which may be converted into enantiomerically pure threo (2S,3R) β-hydroxy-α-amino acids (3) in excellent yield.

The structure taste relationships of the dipeptide esters composed of L aspartic acid and β hydroxy amino acids

Ariyoshi,Yasuda Yamatani

, p. 326 - 330 (2007/10/05)

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