208943-28-6Relevant articles and documents
Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry
Meloni, Marco M.,White, Peter D.,Armour, Duncan,Brown, Richard C.D.
, p. 299 - 311 (2007/10/03)
Straightforward syntheses of two tert-alkoxysilyl chloride functionalised resins 3 and 31 that allow facile attachment of 1°, 2°, 3° alcohols and phenols to the solid-phase have been achieved. Resin 3 displayed useful loading levels (0.7 mmol/g), and it was stable to storage in activated form. Siloxanes from reaction of 3 with alcohols and phenols were compatible with a variety of reaction conditions commonly used in solid-phase synthesis.
Pd- mediated C-C bond formation with olefins and acetylenes on solid support: A scope and limitations study
Berteina, Sabine,Wendeborn, Sebastian,Brill, Wolfgang K.-D.,De Mesmaeker, Alain
, p. 676 - 678 (2007/10/03)
In this paper we report the scope and limitations of Pd(0)-mediated coupling reactions between aromatic iodides linked to a polystyrene resin and terminal acetylenes and olefins (Heck reactions). Optimized reaction conditions were evaluated with a number of different reagents. The optimized reaction conditions were frequently found to be superior to those previously reported in the literature and resulted in excellent yields of the products upon cleavage from the solid phase.
