10602-07-0

Basic information

• Product Name: Benzenemethanol, 3-ethynyl-
• CAS NO: 10602-07-0
• Molecular Formula: C9H8O
• Molecular Weight: 132.162
• Mol File: 10602-07-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 3-ethynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3-ethynyl-(10602-07-0)
• EPA Substance Registry System: Benzenemethanol, 3-ethynyl-(10602-07-0)

Safety Data

• Hazardous Substances Data: 10602-07-0(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 3-ethynyl- is a chemical compound with the molecular formula C9H8O. It is also known as 3-Ethynylphenylmethanol or 3-Ethynylbenzyl alcohol. Benzenemethanol, 3-ethynyl- is a colorless to light yellow liquid with a faint odor. It is commonly used in the synthesis of various pharmaceutical and organic compounds. It is also utilized as a building block in the production of active pharmaceutical ingredients and agrochemicals. Additionally, it is employed in the manufacturing of flavor and fragrance additives, as well as in the creation of polymers and other specialty chemicals. It is important to handle this chemical with care, as it can cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 10602-06-9 methyl 3-ethynylbenzoate 
• 208943-28-6 4-[3-(hydroxymethyl)phenyl]-2-methylbut-3-yn-2-ol 
• 696-41-3 m-iodobenzaldehyde 
• 95785-27-6 3-(3-hydroxy-3-methylbut-1-yn-1-yl)benzaldehyde 
• 1007587-63-4 3-(trimethylsilyleth-1-yn-1-yl)benzyl alcohol 
• 15852-73-0 (3-Bromophenyl)methanol 
• 3132-99-8 m-bromobenzoic aldehyde 
• 57455-06-8 3-iodobenzylalcohol 

Downstream Products

• 313648-43-0 1,8-di{2-[3-(hydroxymethyl)phenyl]-1-ethynyl}-10-methoxyanthracene 
• 731810-28-9 acetic acid 3-ethynyl-benzyl ester 
• 1007587-51-0 C₁₆H₁₅N₃O₂ 
• 1007587-53-2 C₁₆H₁₅N₃O₂ 
• 1007587-50-9 C₁₆H₁₅N₃O₂ 
• 1195902-19-2 2-((3-(hydroxymethyl)phenyl)ethynyl)benzaldehyde 
• 313648-47-4 1,8-di{2-[3-(bromomethyl)phenyl]-1-ethynyl}-10-methoxyanthracene 
• 158520-43-5 1,3-dihydroxy-2-(3-ethynylphenyl)-4,4,5,5-tetramethylimidazolidine 
• 131458-55-4 meta-ethynyl-(4,4,5,5-tetramethyl-4,5-dihydro-1H-3-(N-oxide)-imidazol-1-yloxyl)-phenyl 

Relevant articles and documents

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first step of which entails the activation of a SUMO protein through an ATP-dependent process catalyzed by SUMO-activating enzyme (SAE). Here, we describe the identification of TAK-981, a mechanism-based inhibitor of SAE which forms a SUMO-TAK-981 adduct as the inhibitory species within the enzyme catalytic site. Optimization of selectivity against related enzymes as well as enhancement of mean residence time of the adduct were critical to the identification of compounds with potent cellular pathway inhibition and ultimately a prolonged pharmacodynamic effect and efficacy in preclinical tumor models, culminating in the identification of the clinical molecule TAK-981.

APOPTOSIS INHIBITORS

The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

GPR40 agonist and its application

The invention provides a novel benzyne compound and its stereisomer, salt, hydrate or crystal for adjusting G protein coupled receptor 40 (GPR40) functions and especially for preventing or treating diabetes. The invention also provides a useful intermedia