20895-79-8

Upstream product

• 765-50-4 2-Chloromethylthiophene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 36331-49-4 2-thiophenecarbaldehyde tosylhydrazone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 
• 21727-45-7 trimethyl-[2]thienylmethyl-ammonium; iodide 

Downstream Products

• 73838-08-1 1-(2-Thienyl)-1-(p-toluenesulfonyl)-4-methylpent-3-ene 
• 73838-20-7 2-[2-Phenyl-1-(toluene-4-sulfonyl)-ethyl]-thiophene 
• 1563173-98-7 C₁₇H₁₄O₂S₃ 
• 73838-11-6 2-[1-Benzyl-4-methyl-1-(toluene-4-sulfonyl)-pent-3-enyl]-thiophene 
• 73838-14-9 7-Ethyl-4,4-dimethyl-7-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-benzo[b]thiophene 
• 73838-10-5 2-[1-Ethyl-4-methyl-1-(toluene-4-sulfonyl)-pent-3-enyl]-thiophene 
• 4861-59-0 2-isohexylthiophene 
• 82112-38-7 dl-1-(2-theinyl)-1-(p-toluenesulfonyl)-4,8-dimethyl-3-(E),7-nonadiene 
• 82112-41-2 2-[(Z)-4,8-Dimethyl-1-(toluene-4-sulfonyl)-nona-3,7-dienyl]-thiophene 
• 73838-19-4 2-[1-(Toluene-4-sulfonyl)-propyl]-thiophene 
• 73838-21-8 1-(2-Thienyl)-1-(p-toluenesulfonyl)propan-3-ol 
• 34715-92-9 (4-nitro-phenyl)-thiophen-2-yl-methanone 

Relevant academic research and scientific papers

A general and practical sulfonylation of benzylic ammonium salts with sulfonyl hydrazides for the synthesis of sulfones

A practical and efficient approach adopting transition-metal-free cross-coupling of sulfonyl hydrazides with benzyl ammonium salts has been developed to synthesize benzyl sulfones using Cs2CO3 as base under mild conditions. The protocol employs stable and easy to handle coupling partners, and is endowed with good substrate compatibility, leading to functional benzyl sulfones in good yields.

Efficient synthesis of aliphatic sulfones by Mg mediated coupling reactions of sulfonyl chlorides and aliphatic halides

Sulfonyl chlorides were reduced to anhydrous sulfinate salts with magnesium under sonication. These sulfinates were alkylated to sulfones with alkyl chlorides in the presence of catalytic sodium iodide under sonication. A variety of aliphatic sulfones was efficiently prepared by this one-pot two-step procedure.

Iron(III) phthalocyanine-chloride-catalyzed synthesis of sulfones from sulfonylhydrazones

In this study, sulfones are synthesized from sulfonylhydrazones catalyzed by iron(III) phthalocyanine chloride. This reaction offers broad substrate scope, occurs under mild conditions, utilized readily available reactants, and forms products in good-to-h

Homolytic Displacement at Saturated Carbon in Organocobalamines. Part 4

Benzyl and para-substituted benzylcobaloximes react with substituted arenesulphonyl chlorides under photochemical and anaerobic conditions at 0 deg C to give a variety of products including the sulphones, bibenzyls, and benzyl ethers of dimethylglyoxime in variable yields.However, when the reactions are carried out in the presence of a 1 mol excess of pyridine, the yield of sulphones is increased by at least 20percent in each case.The corresponding yield of bibenzyls is decreased and no trace of the benzyl ether of dimethylglyoxime is formed.On the other hand, the reaction of heteroaromatic methyl cobaloximes with arenesulphonyl chlorides form the corresponding sulphones as the exclusive organic product in good yield and with no side products.The reactions are interpreted in terms of a direct attack of the arenesulphonyl radical on the α carbon of the benzyl and heteroaromatic methyl ligand.

THERMOLYSIS OF SODIUM SALTS OF TOSYLHYDRAZONES OF SOME HETEROCYCLIC ALDEHYDES IN THE PRESENCE OF SILVER CHROMATE: 1,3 NC MIGRATION OF TOSYL GROUP

The thermal decompositions of sodium salts of tosylhydrazones of furfural, thiophene-2-aldehyde, 1-methylpyrrole-2-aldehyde, and pyridine-2-aldehyde in the presence of silver chromate gave 2-furyl(p-toluenesulfonyl)methane, thiophene-2-(p-toluenesulfonyl)methane, 1-methylpyrrole-2-(p-toluenesulfonyl)methane, and pyridine-2-(p-toluenesulfonyl)methane, respectively, via 1,3 NC migration of tosyl group.The same type of reactions with sodium salts of tosylhydrazones of thiophene-3-aldehyde, pyridine-3-aldehyde, and pyridine-4-aldehyde also afforded the corresponding p-toluenesulfonylmethanes but the yields were slightly lower comparing to the above cases.

4,5,6,7-Tetrahydrobenzothiophenes via Diisobutylaluminum Hydride Mediated Detosylation Reactions

A novel synthesis of 4,4-dimethyl-4,5,6,7-tetrahydrobenzothiophene (3a), its 7-substituted derivatives 3b-d and also 7,7-dimethyl-4,5,6,7-tetrahydrobenzothiophene (12b) is presented.The strategy centers on the facile diisobutylaluminum hydride media