208988-99-2Relevant academic research and scientific papers
Synthesis and receptor binding properties of 2β-alkynyl and 2β-(1,2,3-triazol)substituted 3β-(substituted phenyl)tropane derivatives
Jin, Chunyang,Navarro, Hernan A.,Carroll, F. Ivy
, p. 5529 - 5535 (2008/12/20)
A series of 2β-alkynyl and 2β-(1,2,3-triazol)substituted 3β-(substituted phenyl)tropanes were synthesized and evaluated for affinities at dopamine, serotonin, and norepinephrine membrane transporters using competitive radioligand binding assays. All teste
Tropane derivatives and method for their synthesis
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Page column 24, (2010/11/29)
A compound of formula (I) wherein R1-R6have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of f
Synthesis and biological evaluation of 2-substituted 3β-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters
Xu, Lifen,Izenwasser, Sari,Katz, Jonathan L.,Kopajtic, Theresa,Klein-Stevens, Cheryl,Zhu, Naiju,Lomenzo, Stacey A.,Winfield, Leyte,Trudell, Mark L.
, p. 1203 - 1210 (2007/10/03)
A series of eight 2-substituted 3-tolyltropane derivatives were synthesized, and the in vitro and in vivo biological activities as dopamine uptake inhibitors were determined. From the in vitro structure-activity data, it is apparent that a tolyl group in
Synthesis and biological properties of new 2β-alkyl- and 2β-aryl-3- (substituted phenyl)tropane derivatives: Stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters
Kozikowski, Alan P.,Araldi, Gian Luca,Prakash,Zhang, Mei,Johnson, Kenneth M.
, p. 4973 - 4982 (2007/10/03)
In our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, we have been involved in efforts to further elucidate the nature of cocaine's binding to the dopamine transporter (DAT) through strategic modifications
