307519-45-5Relevant articles and documents
Synthesis and receptor binding properties of 2β-alkynyl and 2β-(1,2,3-triazol)substituted 3β-(substituted phenyl)tropane derivatives
Jin, Chunyang,Navarro, Hernan A.,Carroll, F. Ivy
, p. 5529 - 5535 (2008/12/20)
A series of 2β-alkynyl and 2β-(1,2,3-triazol)substituted 3β-(substituted phenyl)tropanes were synthesized and evaluated for affinities at dopamine, serotonin, and norepinephrine membrane transporters using competitive radioligand binding assays. All teste
Synthesis and Monoamine Transporter Binding of 2-(Diarylmethoxymethyl)-3β-aryltropane Derivatives
Xu, Lifen,Kulkarni, Santosh S.,Izenwasser, Sari,Katz, Jonathan L.,Kopajtic, Theresa,Lomenzo, Stacey A.,Newman, Amy Hauck,Trudell, Mark L.
, p. 1676 - 1682 (2007/10/03)
3β-Aryltropane analogues wherein the 2-position was substituted with various diarylmethoxyalkyl groups were synthesized and evaluated for binding at the dopamine transporter (DAT), serotonin transporter (SERT), norepinephrine transporter (NET), and muscar
Synthesis and biological evaluation of 2-substituted 3β-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters
Xu, Lifen,Izenwasser, Sari,Katz, Jonathan L.,Kopajtic, Theresa,Klein-Stevens, Cheryl,Zhu, Naiju,Lomenzo, Stacey A.,Winfield, Leyte,Trudell, Mark L.
, p. 1203 - 1210 (2007/10/03)
A series of eight 2-substituted 3-tolyltropane derivatives were synthesized, and the in vitro and in vivo biological activities as dopamine uptake inhibitors were determined. From the in vitro structure-activity data, it is apparent that a tolyl group in
Synthesis and biological properties of new 2β-alkyl- and 2β-aryl-3- (substituted phenyl)tropane derivatives: Stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters
Kozikowski, Alan P.,Araldi, Gian Luca,Prakash,Zhang, Mei,Johnson, Kenneth M.
, p. 4973 - 4982 (2007/10/03)
In our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, we have been involved in efforts to further elucidate the nature of cocaine's binding to the dopamine transporter (DAT) through strategic modifications